Gene
cbx7a
- ID
- ZDB-GENE-050417-400
- Name
- chromobox homolog 7a
- Symbol
- cbx7a Nomenclature History
- Previous Names
-
- zgc:110152
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable SUMO binding activity and SUMO ligase activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II and protein sumoylation. Predicted to act upstream of or within negative regulation of DNA-templated transcription. Predicted to be part of PRC1 complex. Is expressed in several structures, including digestive system; eye; heart; pectoral fin bud; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in breast cancer; multiple myeloma; and myeloid leukemia. Orthologous to human CBX7 (chromobox 7).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:110152 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-cbx7a | Pham et al., 2024 | |
| CRISPR2-cbx7a | Pham et al., 2024 | |
| MO1-cbx7a | N/A | Huang et al., 2013 |
| MO2-cbx7a | N/A | Pham et al., 2024 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | CBX family C-terminal motif | Chromo/chromo shadow domain | Chromo domain | Chromo domain, conserved site | Chromo domain subgroup | Chromo-like domain superfamily | E3 SUMO-protein ligase CBX4 |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2BJD8 | InterPro | 307 | |||||||
| UniProtKB:Q568R0 | InterPro | 393 | |||||||
| UniProtKB:A0A8M1N5K1 | InterPro | 393 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-369F20 | ||
| Encodes | cDNA | MGC:110152 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192643 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001017853 (1) | 2096 nt | ||
| Genomic | GenBank:CU463950 (2) | 46408 nt | ||
| Polypeptide | UniProtKB:A0A8M1N5K1 (1) | 393 aa |
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Human | CBX7 | 22 | Amino acid sequence comparison (1) |
- Lu, X., Zhang, L., Lin, G.M., Lu, J.G., Cui, Z.B. (2024) Analysis of Differential Gene Expression under Acute Lead or Mercury Exposure in Larval Zebrafish Using RNA-Seq. Animals : an open access journal from MDPI. 14(19):
- Pham, V.C., Rödel, C.J., Valentino, M., Malinverno, M., Paolini, A., Münch, J., Pasquier, C., Onyeogaziri, F.C., Lazovic, B., Girard, R., Koskimäki, J., Hußmann, M., Keith, B., Jachimowicz, D., Kohl, F., Hagelkruys, A., Penninger, J.M., Schulte-Merker, S., Awad, I.A., Hicks, R., Magnusson, P.U., Faurobert, E., Pagani, M., Abdelilah-Seyfried, S. (2024) Epigenetic regulation by polycomb repressive complex 1 promotes cerebral cavernous malformations. EMBO Molecular Medicine. 16(11):2827-2855
- Liu, X., Jones, W.D., Quesnel-Vallières, M., Devadiga, S.A., Lorent, K., Valvezan, A.J., Myers, R.L., Li, N., Lengner, C.J., Barash, Y., Pack, M., Klein, P.S. (2023) The Tumor Suppressor Adenomatous Polyposis Coli (apc) Is Required for Neural Crest-Dependent Craniofacial Development in Zebrafish. Journal of developmental biology. 11(3):
- Gans, I., Hartig, E.I., Zhu, S., Tilden, A.R., Hutchins, L.N., Maki, N.J., Graber, J.H., Coffman, J.A. (2020) Klf9 is a key feedforward regulator of the transcriptomic response to glucocorticoid receptor activity. Scientific Reports. 10:11415
- Raby, L., Völkel, P., Le Bourhis, X., Angrand, P.O. (2020) The Polycomb Orthologues in Teleost Fishes and Their Expression in the Zebrafish Model. Genes. 11(4):
- Huo, X., Li, H., Li, Z., Yan, C., Agrawal, I., Mathavan, S., Liu, J., Gong, Z. (2019) Transcriptomic profiles of tumor-associated neutrophils reveal prominent roles in enhancing angiogenesis in liver tumorigenesis in zebrafish. Scientific Reports. 9:1509
- Takada, N., Omae, M., Sagawa, F., Chi, N.C., Endo, S., Kozawa, S., Sato, T.N. (2017) Re-evaluating functional landscape of the cardiovascular system during development. Biology Open. 6(11):1756-1770
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Baumgart, M., Groth, M., Priebe, S., Savino, A., Testa, G., Dix, A., Ripa, R., Spallotta, F., Gaetano, C., Ori, M., Terzibasi Tozzini, E., Guthke, R., Platzer, M., Cellerino, A. (2014) RNA-seq of the aging brain in the short-lived fish N. furzeri - conserved pathways and novel genes associated with neurogenesis. Aging Cell. 13(6):965-74
- Benard, E.L., Roobol, S.J., Spaink, H.P., Meijer, A.H. (2014) Phagocytosis of mycobacteria by zebrafish macrophages is dependent on the scavenger receptor Marco, a key control factor of pro-inflammatory signalling. Developmental and comparative immunology. 47(2):223-33
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