Gene

cbx7a

ID
ZDB-GENE-050417-400
Name
chromobox homolog 7a
Symbol
cbx7a Nomenclature History
Previous Names
  • zgc:110152
Type
protein_coding_gene
Location
Chr: 3 Mapping Details/Browsers
Description
Predicted to enable SUMO binding activity and SUMO ligase activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II and protein sumoylation. Predicted to act upstream of or within negative regulation of DNA-templated transcription. Predicted to be part of PRC1 complex. Is expressed in several structures, including digestive system; eye; heart; pectoral fin bud; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in breast cancer; multiple myeloma; and myeloid leukemia. Orthologous to human CBX7 (chromobox 7).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
7 figures from 6 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
pbb62Allele with one deletionUnknownUnknownCRISPR
sa33170Allele with one point mutationUnknownPremature StopENU
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Sequence Targeting Reagents
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Human Disease
Associated With cbx7a Human Ortholog
No data available
Associated With cbx7a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR023779 Chromo domain, conserved site
Conserved_site IPR033773 CBX family C-terminal motif
Domain IPR000953 Chromo/chromo shadow domain
Domain IPR017984 Chromo domain subgroup
Domain IPR023780 Chromo domain
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Domain Details Per Protein
Protein Additional Resources Length CBX family C-terminal motif Chromo/chromo shadow domain Chromo domain Chromo domain, conserved site Chromo domain subgroup Chromo-like domain superfamily E3 SUMO-protein ligase CBX4
UniProtKB:A0A8M2BJD8 InterPro 307
UniProtKB:Q568R0 InterPro 393
UniProtKB:A0A8M1N5K1 InterPro 393
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 3
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA cbx7a-201 (1) Ensembl 2,064 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH73-369F20
EncodescDNAMGC:110152ZFIN Curated Data
EncodescDNAMGC:192643ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanCBX722
Amino acid sequence comparison (1)
Citations
1 - 10 of 16
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