Gene
cbx7a
- ID
- ZDB-GENE-050417-400
- Name
- chromobox homolog 7a
- Symbol
- cbx7a Nomenclature History
- Previous Names
-
- zgc:110152
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable SUMO binding activity and SUMO ligase activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II and protein sumoylation. Predicted to act upstream of or within negative regulation of DNA-templated transcription. Predicted to be part of PRC1 complex. Is expressed in several structures, including digestive system; eye; heart; pectoral fin bud; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in breast cancer; multiple myeloma; and myeloid leukemia. Orthologous to human CBX7 (chromobox 7).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:110152 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR023779 | Chromo domain, conserved site |
| Conserved_site | IPR033773 | CBX family C-terminal motif |
| Domain | IPR000953 | Chromo/chromo shadow domain |
| Domain | IPR017984 | Chromo domain subgroup |
| Domain | IPR023780 | Chromo domain |
| Family | IPR043531 | E3 SUMO-protein ligase CBX4 |
| Homologous_superfamily | IPR016197 | Chromo-like domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | CBX family C-terminal motif | Chromo/chromo shadow domain | Chromo domain | Chromo domain, conserved site | Chromo domain subgroup | Chromo-like domain superfamily | E3 SUMO-protein ligase CBX4 |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2BJD8 | InterPro | 307 | |||||||
| UniProtKB:Q568R0 | InterPro | 393 | |||||||
| UniProtKB:A0A8M1N5K1 | InterPro | 393 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available