Gene
twist1b
- ID
- ZDB-GENE-050417-357
- Name
- twist family bHLH transcription factor 1b
- Symbol
- twist1b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Enables cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including circulatory system development; pharyngeal system development; and regulation of bone mineralization. Is expressed in several structures, including brain; cardiovascular system; cranial vault; mesoderm; and pharyngeal arch. Human ortholog(s) of this gene implicated in Sweeney-Cox syndrome; breast cancer (multiple); and synostosis (multiple). Orthologous to human TWIST1 (twist family bHLH transcription factor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 26 figures from 18 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Yang et al., 2011
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-twist1b | Mahmoud et al., 2016 | |
| CRISPR2-twist1b | (2) | |
| CRISPR3-twist1b | (2) | |
| CRISPR4-twist1b | Gunawan et al., 2020 | |
| CRISPR5-twist1b | Gunawan et al., 2020 | |
| MO1-twist1b | N/A | Yang et al., 2011 |
| MO2-twist1b | N/A | Yang et al., 2011 |
| MO3-twist1b | N/A | (2) |
| MO4-twist1b | N/A | (2) |
| TALEN1-twist1b | Teng et al., 2018 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| craniosynostosis 1 | Alliance | Craniosynostosis 1 | 123100 |
| Saethre-Chotzen syndrome | Alliance | Robinow-Sorauf syndrome | 180750 |
| Saethre-Chotzen syndrome | Alliance | Saethre-Chotzen syndrome with or without eyelid anomalies | 101400 |
| Sweeney-Cox syndrome | Alliance | Sweeney-Cox syndrome | 617746 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR011598 | Myc-type, basic helix-loop-helix (bHLH) domain |
| Domain | IPR047093 | Twist-related protein 1, basic helix-loop-helix domain |
| Family | IPR050283 | E-box Binding Transcriptional Regulators |
| Homologous_superfamily | IPR036638 | Helix-loop-helix DNA-binding domain superfamily |
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Domain Details Per Protein
| Protein | Length | E-box Binding Transcriptional Regulators | Helix-loop-helix DNA-binding domain superfamily | Myc-type, basic helix-loop-helix (bHLH) domain | Twist-related protein 1, basic helix-loop-helix domain |
|---|---|---|---|---|---|
|
UniProtKB:A0A8M3ATB8
|
133 | ||||
|
UniProtKB:A0A8M9PJG9
|
142 | ||||
|
UniProtKB:Q568M7
|
169 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
twist1b-201
(1)
|
Ensembl | 1,215 nt | ||
| mRNA |
twist1b-202
(1)
|
Ensembl | 944 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| TgBAC(twist1b:GFP) |
|
| 1 | (2) | |
| Tg(UAS:dntwist1b-2A-GFP) |
| 1 | Gunawan et al., 2020 | ||
| Tg(UAS:dntwist1b,UAS:mCherry-CAAX,myl7:EGFP) |
| 1 | (3) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-181M7 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-10F11 | ||
| Encodes | cDNA | MGC:110208 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001017820 (1) | 1226 nt | ||
| Genomic | GenBank:BX005389 | 221363 nt | ||
| Polypeptide | UniProtKB:Q568M7 (1) | 169 aa |
- Carey, C.M., Hollins, H.L., Schmid, A.V., Gagnon, J.A. (2024) Distinct features of the regenerating heart uncovered through comparative single-cell profiling. Biology Open. 13(4):
- Murayama, E., Vivier, C., Schmidt, A., Herbomel, P. (2023) Alcam-a and Pdgfr-α are essential for the development of sclerotome-derived stromal cells that support hematopoiesis. Nature communications. 14:11711171
- Liu, Y., Kassack, M.E., McFaul, M.E., Christensen, L.N., Siebert, S., Wyatt, S.R., Kamei, C.N., Horst, S., Arroyo, N., Drummond, I.A., Juliano, C.E., Draper, B.W. (2022) Single-cell transcriptome reveals insights into the development and function of the zebrafish ovary. eLIFE. 11:
- Fukui, H., Chow, R.W., Xie, J., Foo, Y.Y., Yap, C.H., Minc, N., Mochizuki, N., Vermot, J. (2021) Bioelectric signaling and the control of cardiac cell identity in response to mechanical forces. Science (New York, N.Y.). 374:351-354
- Jacob, T., Chakravarty, A., Panchal, A., Patil, M., Ghodadra, G., Sudhakaran, J., Nuesslein-Volhard, C. (2021) Zebrafish twist2/dermo1 regulates scale shape and scale organization during skin development and regeneration. Cells & development. 166:203684
- Klatt Shaw, D., Saraswathy, V.M., Zhou, L., McAdow, A.R., Burris, B., Butka, E., Morris, S.A., Dietmann, S., Mokalled, M.H. (2021) Localized EMT reprograms glial progenitors to promote spinal cord repair. Developmental Cell. 56(5):613-626.e7
- Peng, Y., Wang, W., Fang, Y., Hu, H., Chang, N., Pang, M., Hu, Y.F., Li, X., Long, H., Xiong, J.W., Zhang, R. (2021) Inhibition of TGF-β/Smad3 Signaling Disrupts Cardiomyocyte Cell Cycle Progression and Epithelial-Mesenchymal Transition-Like Response During Ventricle Regeneration. Frontiers in cell and developmental biology. 9:632372
- Postlethwait, J.H., Massaquoi, M.S., Farnsworth, D.R., Yan, Y.L., Guillemin, K., Miller, A.C. (2021) The SARS-CoV-2 receptor and other key components of the Renin-Angiotensin-Aldosterone System related to COVID-19 are expressed in enterocytes in larval zebrafish. Biology Open. 10(3):
- Espanola, S.G., Song, H., Ryu, E., Saxena, A., Kim, E.S., Manegold, J.E., Nasamran, C.A., Sahoo, D., Oh, C.K., Bickers, C., Shin, U., Grainger, S., Park, Y.H., Pandolfo, L., Kang, M.S., Kang, S., Myung, K., Cooper, K.L., Yelon, D., Traver, D., Lee, Y. (2020) Haematopoietic stem cell-dependent Notch transcription is mediated by p53 through the Histone chaperone Supt16h. Nature cell biology. 22(12):1411-1422
- Gunawan, F., Gentile, A., Gauvrit, S., Stainier, D., Bensimon-Brito, A. (2020) Nfatc1 Promotes Interstitial Cell Formation During Cardiac Valve Development in Zebrafish. Circulation research. 126(8):968-984
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