Gene

rras2

ID

ZDB-GENE-050417-352

Name

RAS related 2

Symbol

rras2 Nomenclature History

Previous Names

wu:fc47b08
zgc:110215

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Predicted to have GDP binding activity; GTP binding activity; and GTPase activity. Predicted to be involved in Ras protein signal transduction. Predicted to localize to plasma membrane. Human ortholog(s) of this gene implicated in Noonan syndrome. Is expressed in several structures, including adaxial cell; head mesenchyme; hindbrain neural plate; musculature system; and notochord. Orthologous to human RRAS2 (RAS related 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:110215 (14 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With rras2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Noonan syndrome 12	Alliance	Noonan syndrome 12	618624
		Ovarian carcinoma

Associated With rras2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR005225	Small GTP-binding domain
Family	IPR001806	Small GTPase
Family	IPR020849	Small GTPase, Ras-type
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase