ZFIN is now using GRCz12tu for Genomic Data
Gene
rras2
- ID
- ZDB-GENE-050417-352
- Name
- RAS related 2
- Symbol
- rras2 Nomenclature History
- Previous Names
-
- wu:fc47b08
- zgc:110215
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable GTPase activity. Predicted to be involved in Ras protein signal transduction and establishment or maintenance of cell polarity. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including adaxial cell; head mesenchyme; hindbrain neural plate; musculature system; and notochord. Human ortholog(s) of this gene implicated in Noonan syndrome 12. Orthologous to human RRAS2 (RAS related 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:110215 (14 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Noonan syndrome 12 | Alliance | Noonan syndrome 12 | 618624 |
| Ovarian carcinoma |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | P-loop containing nucleoside triphosphate hydrolase | Small GTPase | Small GTPase, Ras-type | Small GTP-binding domain |
|---|---|---|---|---|---|---|
| UniProtKB:Q568M0 | InterPro | 202 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers