Gene
ctrb.3
- ID
- ZDB-GENE-050417-229
- Name
- chymotrypsinogen B, tandem duplicate 3
- Symbol
- ctrb.3 Nomenclature History
- Previous Names
-
- zgc:112160
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in extracellular region. Orthologous to several human genes including CTRB1 (chymotrypsinogen B1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Chung et al., 2011
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Active_site | IPR018114 | Serine proteases, trypsin family, histidine active site |
Active_site | IPR033116 | Serine proteases, trypsin family, serine active site |
Domain | IPR001254 | Serine proteases, trypsin domain |
Family | IPR001314 | Peptidase S1A, chymotrypsin family |
Homologous_superfamily | IPR009003 | Peptidase S1, PA clan |
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Domain Details Per Protein
Protein | Additional Resources | Length | Peptidase S1A, chymotrypsin family | Peptidase S1, PA clan | Peptidase S1, PA clan, chymotrypsin-like fold | Serine proteases, trypsin domain | Serine proteases, trypsin family, histidine active site | Serine proteases, trypsin family, serine active site |
---|---|---|---|---|---|---|---|---|
UniProtKB:Q561U4 | InterPro | 265 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
zgc:112160-201
(1)
|
Ensembl | 1,588 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-193L8 | ZFIN Curated Data | |
Encodes | cDNA | MGC:112160 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001017724 (1) | 1602 nt | ||
Genomic | GenBank:CR356247 (1) | 211785 nt | ||
Polypeptide | UniProtKB:Q561U4 (1) | 265 aa |
Species | Symbol | Chromosome | Accession # | Evidence |
---|---|---|---|---|
Human | CTRB1 | 16 | Amino acid sequence comparison (1) Conserved genome location (synteny) (1) Phylogenetic tree (1) | |
Human | CTRB2 | 16 | Conserved genome location (synteny) (1) Amino acid sequence comparison (1) Phylogenetic tree (1) | |
Mouse | Ctrb1 | 8 | Conserved genome location (synteny) (1) Amino acid sequence comparison (1) Phylogenetic tree (1) |
- Jiang, J., Chen, L., Wu, S., Lv, L., Liu, X., Wang, Q., Zhao, X. (2020) Effects of difenoconazole on hepatotoxicity, lipid metabolism and gut microbiota in zebrafish (Danio rerio). Environmental pollution (Barking, Essex : 1987). 265:114844
- Orosz, F. (2015) On the tubulin polymerization promoting proteins of zebrafish. Biochemical and Biophysical Research Communications. 457(3):267-72
- Chung, A.Y., Kim, S., Kim, H., Bae, Y.K., and Park, H.C. (2011) Microarray Screening for Genes Involved in Oligodendrocyte Differentiation in the Zebrafish CNS. Experimental Neurobiology. 20(2):85-91
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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