Gene

afmid

ID

ZDB-GENE-050417-166

Name

arylformamidase

Symbol

afmid Nomenclature History

Previous Names

im:7148587
zgc:112472

Type

protein_coding_gene

Location

Chr: 11 Mapping Details/Browsers

Description

Predicted to enable arylformamidase activity. Predicted to be involved in L-tryptophan catabolic process to kynurenine. Predicted to act upstream of or within L-tryptophan catabolic process. Predicted to be located in cytosol and nucleus. Predicted to be active in cytoplasm. Orthologous to human AFMID (arylformamidase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7148587 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

No data available

Sequence Targeting Reagents

No data available

Human Disease

Associated With afmid Human Ortholog

No data available

Associated With afmid Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR013094	Alpha/beta hydrolase fold-3
Family	IPR027519	Kynurenine formamidase, vertebrates/fungi-type
Family	IPR050300	GDXG lipolytic enzyme
Homologous_superfamily	IPR029058	Alpha/Beta hydrolase fold

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:A0A0R4IZ99	InterPro	293
UniProtKB:Q566U4	InterPro	293
UniProtKB:B2GQ61	InterPro	269
UniProtKB:A0AB32U3A6	InterPro	269

Transcripts

Genome Browsers

Genome Build: GRCz11Chromosome: 11

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	afmid-202 (1) Ensembl	Ensembl	1,044 nt	Select Tool ZFIN BLAST
mRNA	afmid-203 (1) Ensembl	Ensembl	1,780 nt	Select Tool ZFIN BLAST
mRNA	afmid-204 (1) Ensembl	Ensembl	860 nt	Select Tool ZFIN BLAST
mRNA	afmid-205 (1) Ensembl	Ensembl	1,413 nt	Select Tool ZFIN BLAST
mRNA	afmid-207 (1) Ensembl	Ensembl	796 nt	Select Tool ZFIN BLAST
mRNA	afmid-208 (1) Ensembl	Ensembl	680 nt	Select Tool ZFIN BLAST
ncRNA	afmid-004 (1) Ensembl	Ensembl	794 nt	Select Tool ZFIN BLAST
ncRNA	afmid-005 (1) Ensembl	Ensembl	677 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

No data available

Marker Relationships

Relationship	Marker Type	Marker	Accession Numbers	Citations
Contained in	BAC	DKEY-93H22	CR293511	ZFIN Curated Data
Encodes	EST	IMAGE:7148587	CK685943	Thisse et al., 2004
Encodes	cDNA	MGC:112472	BC093330	ZFIN Curated Data
Encodes	cDNA	MGC:191791	BC164616	ZFIN Curated Data

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Sequences

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_001017677 (1)	1387 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:CR293511 (1)	178953 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:A0A0R4IZ99 (1)	293 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Species	Symbol	Chromosome	Accession #	Evidence
Human	AFMID	17	Ensembl:ENSG00000183077 Gene:125061 HGNC:20910 OMIM:621151	Conserved genome location (synteny) (1) Amino acid sequence comparison (1)
Mouse	Afmid	11	Ensembl:ENSMUSG00000017718 Gene:71562 MGI:2448704	Amino acid sequence comparison (1) Conserved genome location (synteny) (1)

Citations

Include unpublished citations

Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903

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