Gene
myo5ab
- ID
- ZDB-GENE-050411-72
- Name
- myosin VAb
- Symbol
- myo5ab Nomenclature History
- Previous Names
-
- im:7152131
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable actin filament binding activity and microfilament motor activity. Predicted to be involved in actin filament organization and endocytosis. Predicted to be active in actin cytoskeleton; cytoplasm; and membrane. Human ortholog(s) of this gene implicated in Griscelli syndrome type 1. Orthologous to human MYO5A (myosin VA).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7152131 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Griscelli syndrome type 1 | Alliance | Griscelli syndrome, type 1 | 214450 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR000048 | IQ motif, EF-hand binding site |
| Domain | IPR001609 | Myosin head, motor domain-like |
| Domain | IPR002710 | Dilute domain |
| Domain | IPR036103 | Class V myosin, motor domain |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036961 | Kinesin motor domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Class V myosin, motor domain | Dilute domain | IQ motif, EF-hand binding site | Kinesin motor domain superfamily | Myosin head, motor domain-like | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3API9 | InterPro | 1800 | ||||||
| UniProtKB:A0AB32TJE1 | InterPro | 1800 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
myo5ab-201
(1)
|
Ensembl | 5,472 nt | ||
| mRNA |
myo5ab-202
(1)
|
Ensembl | 3,582 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance