Gene
ecscr
- ID
- ZDB-GENE-050411-37
- Name
- endothelial cell surface expressed chemotaxis and apoptosis regulator
- Symbol
- ecscr Nomenclature History
- Previous Names
-
- im:7141253 (1)
- si:dkey-222k23.1
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Acts upstream of or within angioblast cell migration from lateral mesoderm to midline. Predicted to be located in membrane. Is expressed in angioblastic mesenchymal cell; axial blood vessel; mesoderm; and primordial vasculature. Orthologous to human ECSCR (endothelial cell surface expressed chemotaxis and apoptosis regulator).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7141253 (4 images)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Verma et al., 2010
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-ecscr | N/A | Verma et al., 2010 |
| MO2-ecscr | N/A | (2) |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR026247 | Endothelial cell-specific chemotaxis regulator |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Endothelial cell-specific chemotaxis regulator |
|---|---|---|---|
| UniProtKB:E7F0W6 | InterPro | 249 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-222K23 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7141253 | Thisse et al., 2004 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_002666009 (1) | 1271 nt | ||
| Genomic | GenBank:CU463029 (2) | 66900 nt | ||
| Polypeptide | UniProtKB:E7F0W6 (1) | 249 aa |
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Kilari, S., Remadevi, I., Zhao, B., Pan, J., Miao, R., Ramchandran, R., North, P.E., You, M., Rahimi, N., and Wilkinson, G.A. (2013) Endothelial Cell-Specific Chemotaxis Receptor (ECSCR) enhances Vascular Endothelial Growth Factor (VEGF) Receptor-2/Kinase insert domain receptor (KDR) activation and promotes proteolysis of internalized KDR. The Journal of biological chemistry. 288(15):10265-10274
- Verma, A., Bhattacharya, R., Remadevi, I., Li, K., Pramanik, K., Samant, G.V., Horswill, M., Chun, C.Z., Zhao, B., Wang, E., Miao, R.Q., Mukhopadhyay, D., Ramchandran, R., and Wilkinson, G.A. (2010) Endothelial cell-specific chemotaxis receptor (ecscr) promotes angioblast migration during vasculogenesis and enhances VEGF receptor sensitivity. Blood. 115(22):4614-4622
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