Gene
smpdl3a
- ID
- ZDB-GENE-050327-61
- Name
- sphingomyelin phosphodiesterase acid like 3A
- Symbol
- smpdl3a Nomenclature History
- Previous Names
-
- si:ch211-199i15.3
- zgc:113352
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable phosphoric diester hydrolase activity. Predicted to act upstream of or within sphingomyelin catabolic process. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human SMPDL3A (sphingomyelin phosphodiesterase acid like 3A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR004843 | Calcineurin-like phosphoesterase domain, ApaH type |
| Domain | IPR041805 | Acid sphingomyelinase/endopolyphosphatase, metallophosphatase domain |
| Domain | IPR045473 | Sphingomyelin phosphodiesterase, C-terminal domain |
| Family | IPR017064 | Acid sphingomyelinase-like phosphodiesterase, predicted |
| Homologous_superfamily | IPR029052 | Metallo-dependent phosphatase-like |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Acid sphingomyelinase/endopolyphosphatase, metallophosphatase domain | Acid sphingomyelinase-like phosphodiesterase, predicted | Calcineurin-like phosphoesterase domain, ApaH type | Metallo-dependent phosphatase-like | Sphingomyelin phosphodiesterase, C-terminal domain |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q58EN0 | InterPro | 441 | |||||
| UniProtKB:A0A8M3AWG3 | InterPro | 418 | |||||
| UniProtKB:A0A8M2BHJ3 | InterPro | 444 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
smpdl3a-201
(1)
|
Ensembl | 1,589 nt | ||
| mRNA |
smpdl3a-202
(1)
|
Ensembl | 894 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-199I15 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:113352 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001014338 (1) | 1660 nt | ||
| Genomic | GenBank:AL845421 (2) | 148289 nt | ||
| Polypeptide | UniProtKB:A0A8M2BHJ3 (1) | 444 aa |
- Le Mentec, H., Monniez, E., Legrand, A., Monvoisin, C., Lagadic-Gossmann, D., Podechard, N. (2023) A New In Vivo Zebrafish Bioassay Evaluating Liver Steatosis Identifies DDE as a Steatogenic Endocrine Disruptor, Partly through SCD1 Regulation. International Journal of Molecular Sciences. 24(4):
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Roca, F.J., and Ramakrishnan, L. (2013) TNF Dually Mediates Resistance and Susceptibility to Mycobacteria via Mitochondrial Reactive Oxygen Species. Cell. 153(3):521-34
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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