Gene
ptbp2a
- ID
- ZDB-GENE-050320-141
- Name
- polypyrimidine tract binding protein 2a
- Symbol
- ptbp2a Nomenclature History
- Previous Names
-
- zgc:113074 (1)
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to enable mRNA binding activity. Predicted to be involved in regulation of RNA splicing. Predicted to act upstream of or within mRNA processing. Predicted to be active in nucleus. Orthologous to human PTBP2 (polypyrimidine tract binding protein 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:113074 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000504 | RNA recognition motif domain |
| Domain | IPR021790 | PTBP1-like, RNA recognition motif 2 |
| Domain | IPR034800 | PTBP2, RNA recognition motif 4 |
| Family | IPR006536 | HnRNP-L/PTB |
| Homologous_superfamily | IPR012677 | Nucleotide-binding alpha-beta plait domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | HnRNP-L/PTB | Nucleotide-binding alpha-beta plait domain superfamily | PTBP1-like, RNA recognition motif 2 | PTBP2, RNA recognition motif 4 | RNA-binding domain superfamily | RNA recognition motif domain |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M6Z4P9 | InterPro | 319 | ||||||
| UniProtKB:A0A8M6YY33 | InterPro | 490 | ||||||
| UniProtKB:A0A0R4IZG6 | InterPro | 512 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ptbp2a-201
(1)
|
Ensembl | 556 nt | ||
| mRNA |
ptbp2a-202
(1)
|
Ensembl | 1,882 nt | ||
| ncRNA |
ptbp2a-003
(1)
|
Ensembl | 569 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-250G17 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:113074 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192342 | ZFIN Curated Data | |
| Has Artifact | EST | fe26f02 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001328429 (1) | 3660 nt | ||
| Genomic | GenBank:CU896585 (2) | 102146 nt | ||
| Polypeptide | UniProtKB:A0A0R4IZG6 (1) | 512 aa |
- Vejnar, C.E., Abdelmessih, M., Takacs, C., Yartseva, V., Oikonomou, P., Christiano, R., Stoeckius, M., Lau, S., Lee, M., Beaudoin, J.D., Musaev, D., Darwich-Codore, H., Walther, T., Tavazoie, S., Cifuentes, D., Giraldez, A. (2019) Genome wide analysis of 3'-UTR sequence elements and proteins regulating mRNA stability during maternal-to-zygotic transition in zebrafish. Genome research. 29(7):1100-1114
- Petit, D., Teppa, E., Mir, A., Vicogne, D., Thisse, C., Thisse, B., Filloux, C., Harduin-Lepers, A. (2015) Integrative view of α2,3-sialyltransferases (ST3Gal) molecular and functional evolution in deuterostomes: significance of lineage specific losses. Mol. Biol. Evol.. 32(4):906-27
- Hultqvist, G., Daza, D.O., Larhammar, D., and Kilimann, M.W. (2012) Evolution of the vertebrate paralemmin gene family: ancient origin of gene duplicates suggests distinct functions. PLoS One. 7(7):e41850
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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