Gene

ghrhra

ID

ZDB-GENE-050315-2

Name

growth hormone releasing hormone receptor a

Symbol

ghrhra Nomenclature History

Previous Names

GHRH-LPR (1)
ghrhr
PRPR (1)
PRPRA (1)

Type

protein_coding_gene

Location

Chr: 2 Mapping Details/Browsers

Description

Exhibits growth hormone-releasing hormone receptor activity. Involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in isolated growth hormone deficiency. Is expressed in several structures, including eye; gill; gut; heart; and pleuroperitoneal region. Orthologous to human GHRHR (growth hormone releasing hormone receptor).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ghrhra Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
isolated growth hormone deficiency type IB	Alliance	Growth hormone deficiency, isolated, type IV	618157

Associated With ghrhra Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017983	GPCR, family 2, secretin-like, conserved site
Domain	IPR001879	GPCR, family 2, extracellular hormone receptor domain
Domain	IPR017981	GPCR, family 2-like, 7TM
Family	IPR000832	GPCR, family 2, secretin-like
Family	IPR050332	G-protein coupled receptor 2
Homologous_superfamily	IPR036445	GPCR family 2, extracellular hormone receptor domain superfamily