Gene
adcyap1r1a
- ID
- ZDB-GENE-050315-1
- Name
- adenylate cyclase activating polypeptide 1a (pituitary) receptor type I
- Symbol
- adcyap1r1a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable G protein-coupled peptide receptor activity and peptide hormone binding activity. Acts upstream of or within adenylate cyclase-modulating G protein-coupled receptor signaling pathway and phospholipase C-activating G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including central nervous system; eye; gut; heart; and pleuroperitoneal region. Used to study post-traumatic stress disorder. Orthologous to human ADCYAP1R1 (ADCYAP receptor type I).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la023777Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa14546 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| wz18 | Allele with multiple variants | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-adcyap1r1a | (2) | |
| CRISPR2-adcyap1r1a | (2) | |
| MO1-adcyap1r1a | N/A | Amir-Zilberstein et al., 2012 |
| MO2-adcyap1r1a | N/A | Amir-Zilberstein et al., 2012 |
| MO3-adcyap1r1a | N/A | Tam et al., 2012 |
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Human Disease
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| post-traumatic stress disorder | adcyap1r1awz18/wz18 | standard conditions | Biran et al., 2020 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017983 | GPCR, family 2, secretin-like, conserved site |
| Domain | IPR001879 | GPCR, family 2, extracellular hormone receptor domain |
| Domain | IPR017981 | GPCR, family 2-like, 7TM |
| Family | IPR000832 | GPCR, family 2, secretin-like |
| Family | IPR002285 | GPCR, family 2, pituitary adenylate cyclase activating polypeptide type 1 receptor |
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Domain Details Per Protein
| Protein | Additional Resources | Length | GPCR, family 2, extracellular hormone receptor domain | GPCR family 2, extracellular hormone receptor domain superfamily | GPCR, family 2-like, 7TM | GPCR, family 2, pituitary adenylate cyclase activating polypeptide type 1 receptor | GPCR, family 2, secretin-like | GPCR, family 2, secretin-like, conserved site | G-protein coupled receptor 2 |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q5C8U8 | InterPro | 478 | |||||||
| UniProtKB:E7FF76 | InterPro | 445 | |||||||
| UniProtKB:Q5C8U6 | InterPro | 479 | |||||||
| UniProtKB:Q5C8V0 | InterPro | 451 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| aberrant processed transcript |
adcyap1r1a-202
(1)
|
Ensembl | 1,209 nt | ||
| mRNA |
adcyap1r1a-201
(1)
|
Ensembl | 1,102 nt | ||
| mRNA |
adcyap1r1a-203
(1)
|
Ensembl | 9,167 nt | ||
| mRNA |
adcyap1r1a-204
(1)
|
Ensembl | 1,186 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-43K18 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001013444 (1) | 1851 nt | ||
| Genomic | GenBank:CU896637 (2) | 79063 nt | ||
| Polypeptide | UniProtKB:Q5C8U6 (1) | 479 aa |
- Biran, J., Gliksberg, M., Shirat, I., Swaminathan, A., Levitas-Djerbi, T., Appelbaum, L., Levkowitz, G. (2020) Splice-specific deficiency of the PTSD-associated gene PAC1 leads to a paradoxical age-dependent stress behavior. Scientific Reports. 10:9559
- Nakamachi, T., Tanigawa, A., Konno, N., Shioda, S., Matsuda, K. (2019) Expression Patterns of PACAP and PAC1R Genes and Anorexigenic Action of PACAP1 and PACAP2 in Zebrafish. Frontiers in endocrinology. 10:227
- Kasica-Jarosz, N., Podlasz, P., Kaleczyc, J. (2018) Pituitary adenylate cyclase-activating polypeptide (PACAP-38) plays an inhibitory role against inflammation induced by chemical damage to zebrafish hair cells. PLoS One. 13:e0198180
- On, J.S.W., Duan, C., Lee, L.T.O. (2015) Functional pairing of class B1 ligand-GPCR in cephalochordate provides evidence of the origin of PTH and PACAP/glucagonreceptor family. Molecular Biology and Evolution. 32(8):2048-59
- Tam, J.K., Chow, B.K., and Lee, L.T. (2013) Structural and functional divergence of growth hormone-releasing hormone receptors in early sarcopterygians: lungfish and Xenopus. PLoS One. 8(1):e53482
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Amir-Zilberstein, L., Blechman, J., Sztainberg, Y., Norton, W.H., Reuveny, A., Borodovsky, N., Tahor, M., Bonkowsky, J.L., Bally-Cuif, L., Chen, A., and Levkowitz, G. (2012) Homeodomain protein otp and activity-dependent splicing modulate neuronal adaptation to stress. Neuron. 72(2):279-291
- Tam, S.J., Richmond, D.L., Kaminker, J.S., Modrusan, Z., Martin-McNulty, B., Cao, T.C., Weimer, R.M., Carano, R.A., van Bruggen, N., and Watts, R.J. (2012) Death Receptors DR6 and TROY Regulate Brain Vascular Development. Developmental Cell. 22(2):403-417
- Alexandre, D., Alonzeau, J., Bill, B.R., Ekker, S.C., and Waschek, J.A. (2011) Expression Analysis of PAC1-R and PACAP Genes in Zebrafish Embryos. Journal of molecular neuroscience : MN. 43(1):94-100
- Zhou, R., Tsang, A.H., Lau, S.W., and Ge, W. (2011) Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) and Its Receptors in the Zebrafish Ovary: Potential Evidence for Dual Roles of PACAP in Controlling Final Oocyte Maturation. Biology of reproduction. 85(3):615-25
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