Gene

dnmt3ab

ID

ZDB-GENE-050314-3

Name

DNA (cytosine-5-)-methyltransferase 3 alpha b

Symbol

dnmt3ab Nomenclature History

Previous Names

dnmt3a1 (1)
dnmt6

Type

protein_coding_gene

Location

Chr: 17 Mapping Details/Browsers

Description

Predicted to enable DNA (cytosine-5-)-methyltransferase activity; DNA binding activity; and metal ion binding activity. Predicted to be involved in DNA methylation on cytosine and negative regulation of DNA-templated transcription. Predicted to act upstream of or within DNA methylation and regulation of gene expression. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including auditory capsule; digestive system; eye; pleuroperitoneal region; and spinal cord neural tube. Human ortholog(s) of this gene implicated in Tatton-Brown-Rahman syndrome; hematologic cancer (multiple); and stomach cancer. Orthologous to human DNMT3A (DNA methyltransferase 3 alpha).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from 4 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 8 figures from Lai et al., 2020
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With dnmt3ab Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
acute myeloid leukemia	Alliance	Acute myeloid leukemia, somatic	601626
Tatton-Brown-Rahman syndrome	Alliance	Tatton-Brown-Rahman syndrome	615879
		Heyn-Sproul-Jackson syndrome	618724

Associated With dnmt3ab Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR018117	DNA methylase, C-5 cytosine-specific, active site
Domain	IPR000313	PWWP domain
Domain	IPR025766	ADD domain
Domain	IPR040552	DNMT3, cysteine rich ADD domain, GATA1-like zinc finger
Domain	IPR044108	DNA (cytosine-5)-methyltransferase 3A, ADD domain
Domain	IPR049554	DNMT3, ADD domain, PHD zinc finger
Family	IPR001525	C-5 cytosine methyltransferase
Homologous_superfamily	IPR029063	S-adenosyl-L-methionine-dependent methyltransferase superfamily

Domain Details Per Protein

Protein	Length	ADD domain	C-5 cytosine methyltransferase	DNA (cytosine-5)-methyltransferase 3A, ADD domain	DNA methylase, C-5 cytosine-specific, active site	DNMT3, ADD domain, PHD zinc finger	DNMT3, cysteine rich ADD domain, GATA1-like zinc finger	PWWP domain	S-adenosyl-L-methionine-dependent methyltransferase superfamily
UniProtKB:A0A8M9P8W7 InterPro	980
UniProtKB:Q588C4 InterPro	731
UniProtKB:B3DGZ8 InterPro	728
UniProtKB:A0A8M9PE79 InterPro	585
UniProtKB:A0A8M9P050 InterPro	983
UniProtKB:A0A8M3B2J9 InterPro	929
UniProtKB:F1R1K5 InterPro	978

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	dnmt3ab-201 (1) Ensembl	Ensembl	3,363 nt	Select Tool ZFIN BLAST
mRNA	dnmt3ab-202 (1) Ensembl	Ensembl	5,236 nt	Select Tool ZFIN BLAST
mRNA	dnmt3ab-203 (1) Ensembl	Ensembl	7,747 nt	Select Tool ZFIN BLAST
mRNA	dnmt3ab-204 (1) Ensembl	Ensembl	3,190 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations