Gene

dnmt3bb.1

ID

ZDB-GENE-050314-1

Name

DNA (cytosine-5-)-methyltransferase 3 beta, duplicate b.1

Symbol

dnmt3bb.1 Nomenclature History

Previous Names

cb633 (1)
dnmt3b1 (1)
dnmt3b (1)
dnmt4

Type

protein_coding_gene

Location

Chr: 23 Mapping Details/Browsers

Description

Predicted to have DNA-methyltransferase activity. Involved in several processes, including DNA methylation on cytosine within a CG sequence; hematopoietic stem cell homeostasis; and regulation of hematopoietic stem cell differentiation. Human ortholog(s) of this gene implicated in several diseases, including acute myeloid leukemia; autoimmune thrombocytopenic purpura; carcinoma (multiple); immunodeficiency-centromeric instability-facial anomalies syndrome 1; and rheumatoid arthritis. Is expressed in several structures, including digestive system; hematopoietic system; immature eye; mesoderm; and nervous system. Orthologous to human DNMT3B (DNA methyltransferase 3 beta).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

28 figures from 12 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

cb633 (34 images)
IMAGE:7155993 (19 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 10 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With dnmt3bb.1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
facioscapulohumeral muscular dystrophy 4	Alliance	Facioscapulohumeral muscular dystrophy 4, digenic	619478
immunodeficiency-centromeric instability-facial anomalies syndrome 1	Alliance	Immunodeficiency-centromeric instability-facial anomalies syndrome 1	242860

Associated With dnmt3bb.1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR018117	DNA methylase, C-5 cytosine-specific, active site
Domain	IPR000313	PWWP domain
Domain	IPR025766	ADD domain
Domain	IPR030488	DNA (cytosine-5)-methyltransferase 3B, ADD domain
Domain	IPR040552	DNMT3, cysteine rich ADD domain, GATA1-like zinc finger
Domain	IPR049554	DNMT3, ADD domain, PHD zinc finger
Family	IPR001525	C-5 cytosine methyltransferase
Homologous_superfamily	IPR011011	Zinc finger, FYVE/PHD-type
Homologous_superfamily	IPR029063	S-adenosyl-L-methionine-dependent methyltransferase superfamily