Gene
dnmt3bb.1
- ID
- ZDB-GENE-050314-1
- Name
- DNA (cytosine-5-)-methyltransferase 3 beta, duplicate b.1
- Symbol
- dnmt3bb.1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to enable DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates and DNA binding activity. Acts upstream of or within several processes, including Kupffer's vesicle development; hematopoietic stem cell homeostasis; and negative regulation of gene expression via chromosomal CpG island methylation. Predicted to be active in nucleus. Is expressed in several structures, including digestive system; hematopoietic system; immature eye; mesoderm; and nervous system. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); facioscapulohumeral muscular dystrophy 4; immunodeficiency-centromeric instability-facial anomalies syndrome 1; and thymoma. Orthologous to human DNMT3B (DNA methyltransferase 3 beta).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 28 figures from 12 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb633 (34 images)
- IMAGE:7155993 (19 images)
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| b1237 | Allele with one deletion | Unknown | Premature Stop | TALEN | |
| ioz103 | Allele with one delins | Exon 3 | Unknown | CRISPR | |
| la022494Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la022495Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| mk24 | Allele with one deletion | Unknown | Unknown | TALEN | |
| sa12816 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa15458 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| y258 | Allele with one deletion | Exon 6 | Premature Stop | TALEN |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| facioscapulohumeral muscular dystrophy 4 | Alliance | Facioscapulohumeral muscular dystrophy 4, digenic | 619478 |
| immunodeficiency-centromeric instability-facial anomalies syndrome 1 | Alliance | Immunodeficiency-centromeric instability-facial anomalies syndrome 1 | 242860 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR018117 | DNA methylase, C-5 cytosine-specific, active site |
| Domain | IPR000313 | PWWP domain |
| Domain | IPR025766 | ADD domain |
| Domain | IPR030488 | DNA (cytosine-5)-methyltransferase 3B, ADD domain |
| Domain | IPR040552 | DNMT3, cysteine rich ADD domain, GATA1-like zinc finger |
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Domain Details Per Protein
| Protein | Additional Resources | Length | ADD domain | C-5 cytosine methyltransferase | DNA (cytosine-5)-methyltransferase 3B, ADD domain | DNA methylase, C-5 cytosine-specific, active site | DNMT3, ADD domain, PHD zinc finger | DNMT3, cysteine rich ADD domain, GATA1-like zinc finger | PWWP domain | S-adenosyl-L-methionine-dependent methyltransferase superfamily | Zinc finger, FYVE/PHD-type |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3AY81 | InterPro | 768 | |||||||||
| UniProtKB:A0A8M2B8X0 | InterPro | 813 | |||||||||
| UniProtKB:A0A8M3AV60 | InterPro | 753 | |||||||||
| UniProtKB:Q588C6 | InterPro | 816 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
dnmt3bb.1-201
(1)
|
Ensembl | 3,678 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-108P14 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-210I3 | ZFIN Curated Data | |
| Encodes | EST | cb633 | ||
| Encodes | EST | IMAGE:7155993 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:152725 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001025450 (1) | 3544 nt | ||
| Genomic | GenBank:AL929578 (1) | 142570 nt | ||
| Polypeptide | UniProtKB:Q588C6 (1) | 816 aa |
- Gupta, S., Hui, S.P. (2024) Epigenetic Cross-Talk Between Sirt1 and Dnmt1 Promotes Axonal Regeneration After Spinal Cord Injury in Zebrafish. Molecular neurobiology. :
- Lawir, D.F., Soza-Ried, C., Iwanami, N., Siamishi, I., Bylund, G.O., O Meara, C., Sikora, K., Kanzler, B., Johansson, E., Schorpp, M., Cauchy, P., Boehm, T. (2024) Antagonistic interactions safeguard mitotic propagation of genetic and epigenetic information in zebrafish. Communications biology. 7:3131
- Wang, A., Wan, X., Zhu, F., Liu, H., Song, X., Huang, Y., Zhu, L., Ao, Y., Zeng, J., Wang, B., Wu, Y., Xu, Z., Wang, J., Yao, W., Li, H., Zhuang, P., Jiao, J., Zhang, Y. (2024) Habitual Daily Intake of Fried Foods Raises Transgenerational Inheritance Risk of Heart Failure Through NOTCH1-Triggered Apoptosis. Research (Washington, D.C.). 7:04010401
- Wilson, M.L., Romano, S.N., Khatri, N., Aharon, D., Liu, Y., Kaufman, O.H., Draper, B.W., Marlow, F.L. (2024) Rbpms2 promotes female fate upstream of the nutrient sensing Gator2 complex component Mios. Nature communications. 15:52485248
- Liu, Y., Kassack, M.E., McFaul, M.E., Christensen, L.N., Siebert, S., Wyatt, S.R., Kamei, C.N., Horst, S., Arroyo, N., Drummond, I.A., Juliano, C.E., Draper, B.W. (2022) Single-cell transcriptome reveals insights into the development and function of the zebrafish ovary. eLIFE. 11:
- White, R.J., Mackay, E., Wilson, S.W., Busch-Nentwich, E.M. (2022) Allele-specific gene expression can underlie altered transcript abundance in zebrafish mutants. eLIFE. 11:
- Wu, F., Yang, Q., Mi, Y., Wang, F., Cai, K., Zhang, Y., Wang, Y., Wang, X., Gui, Y., Li, Q. (2022) miR-29b-3p Inhibitor Alleviates Hypomethylation-Related Aberrations Through a Feedback Loop Between miR-29b-3p and DNA Methylation in Cardiomyocytes. Frontiers in cell and developmental biology. 10:788799
- Avagyan, S., Henninger, J.E., Mannherz, W.P., Mistry, M., Yoon, J., Yang, S., Weber, M.C., Moore, J.L., Zon, L.I. (2021) Resistance to inflammation underlies enhanced fitness in clonal hematopoiesis. Science (New York, N.Y.). 374:768-772
- Han, J., Hu, Y., Qi, Y., Yuan, C., Naeem, S., Huang, D. (2021) High temperature induced masculinization of zebrafish by down-regulation of sox9b and esr1 via DNA methylation. Journal of environmental sciences (China). 107:160-170
- Liu, Y., Wang, Y., Ling, X., Yan, Z., Wu, D., Liu, J., Lu, G. (2021) Effects of Nanoplastics and Butyl Methoxydibenzoylmethane on Early Zebrafish Embryos Identified by Single-Cell RNA Sequencing. Environmental science & technology. 55(3):1885-1896
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