Gene

dnmt3bb.1

ID
ZDB-GENE-050314-1
Name
DNA (cytosine-5-)-methyltransferase 3 beta, duplicate b.1
Symbol
dnmt3bb.1 Nomenclature History
Previous Names
  • cb633 (1)
  • dnmt3b1 (1)
  • dnmt3b (1)
  • dnmt4
Type
protein_coding_gene
Location
Chr: 23 Mapping Details/Browsers
Description
Predicted to enable DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates and DNA binding activity. Acts upstream of or within several processes, including DNA methylation on cytosine within a CG sequence; Kupffer's vesicle development; and hematopoietic stem cell homeostasis. Predicted to be active in nucleus. Is expressed in several structures, including digestive system; hematopoietic system; immature eye; mesoderm; and nervous system. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); facioscapulohumeral muscular dystrophy; immunodeficiency-centromeric instability-facial anomalies syndrome 1; and thymoma. Orthologous to human DNMT3B (DNA methyltransferase 3 beta).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
28 figures from 12 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
10 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With dnmt3bb.1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
immunodeficiency-centromeric instability-facial anomalies syndrome 1 Alliance Immunodeficiency-centromeric instability-facial anomalies syndrome 1 242860
Facioscapulohumeral muscular dystrophy 4, digenic 619478
Associated With dnmt3bb.1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR018117 DNA methylase, C-5 cytosine-specific, active site
Domain IPR000313 PWWP domain
Domain IPR025766 ADD domain
Domain IPR030488 DNA (cytosine-5)-methyltransferase 3B, ADD domain
Domain IPR040552 DNMT3, cysteine rich ADD domain
Family IPR001525 C-5 cytosine methyltransferase
Homologous_superfamily IPR011011 Zinc finger, FYVE/PHD-type
Domain Details Per Protein
Protein Length ADD domain C-5 cytosine methyltransferase DNA (cytosine-5)-methyltransferase 3B, ADD domain DNA methylase, C-5 cytosine-specific, active site DNMT3, cysteine rich ADD domain PWWP domain Zinc finger, FYVE/PHD-type
UniProtKB:Q08CT6 816
UniProtKB:A0A2R8QML7 806
UniProtKB:Q588C6 816
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations