Gene

btc

ID
ZDB-GENE-050311-1
Name
betacellulin, epidermal growth factor family member
Symbol
btc Nomenclature History
Previous Names
  • zgc:153253
Type
protein_coding_gene
Location
Chr: 21 Mapping Details/Browsers
Description
Predicted to enable epidermal growth factor receptor binding activity and growth factor activity. Predicted to be involved in epidermal growth factor receptor signaling pathway; positive regulation of cell population proliferation; and positive regulation of mitotic nuclear division. Predicted to be located in membrane. Predicted to be active in extracellular space. Is expressed in heart and retina. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus and type 2 diabetes mellitus. Orthologous to human BTC (betacellulin).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
sa19258Allele with one point mutationUnknownPremature StopENU
European Zebrafish Resource Center (EZRC) (order this)
Zebrafish International Resource Center (ZIRC) (order this)
sa23902Allele with one point mutationUnknownPremature StopENU
Zebrafish International Resource Center (ZIRC) (order this)
European Zebrafish Resource Center (EZRC) (order this)
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Sequence Targeting Reagents
No data available
Human Disease
Associated With btc Human Ortholog
No data available
Associated With btc Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000742 EGF-like domain
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Domain Details Per Protein
Protein Additional Resources Length EGF-like domain
UniProtKB:A0A0R4INZ6 InterPro 178
UniProtKB:Q1LVQ0 InterPro 178
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 21
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA btc-201 (1)
Ensembl
Ensembl 1,586 nt
ZFIN BLAST
mRNA btc-202 (1)
Ensembl
Ensembl 1,551 nt
ZFIN BLAST
mRNA btc-203 (1)
Ensembl
Ensembl 2,463 nt
ZFIN BLAST
mRNA btc-204 (1)
Ensembl
Ensembl 1,063 nt
ZFIN BLAST
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACCH211-71C16ZFIN Curated Data
Contained inBACCH211-85E10ZFIN Curated Data
EncodescDNAMGC:153253ZFIN Curated Data
EncodescDNAMGC:162404ZFIN Curated Data
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Sequences
Type Accession # Sequence Length (nt/aa) Analysis
RNARefSeq:NM_001044764 (1)1597 nt
ZFIN BLASTNCBI BLASTEnsemblUCSC BLAT
GenomicGenBank:CR749169180295 nt
MegaBLASTEnsembl
PolypeptideUniProtKB:A0A0R4INZ6 (1)178 aa
ZFIN BLASTSIB BLASTEnsembl Protein Blast
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanBTC4
Amino acid sequence comparison (1)
Citations
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