Gene

lbx1b

ID

ZDB-GENE-050309-27

Name

ladybird homeobox 1b

Symbol

lbx1b Nomenclature History

Previous Names

lbx1
lbx1a (1)
im:7139117

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Involved in muscle cell differentiation. Acts upstream of or within convergent extension and regulation of Wnt signaling pathway. Predicted to be located in nucleus. Is expressed in nervous system; neural plate; neural tube; pectoral fin; and spinal cord neural keel. Human ortholog(s) of this gene implicated in congenital central hypoventilation syndrome. Orthologous to human LBX1 (ladybird homeobox 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

9 figures from 4 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7139117 (10 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Juárez-Morales et al., 2021
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With lbx1b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		?Central hypoventilation syndrome, congenital, 3	619483

Associated With lbx1b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR000047	Helix-turn-helix motif
Conserved_site	IPR017970	Homeobox, conserved site
Domain	IPR001356	Homeodomain
Family	IPR051892	LBX Family Transcription Factors
Homologous_superfamily	IPR009057	Homedomain-like superfamily