Gene

prkra

ID

ZDB-GENE-050309-206

Name

protein kinase, interferon-inducible double stranded RNA dependent activator

Symbol

prkra Nomenclature History

Previous Names

im:7151758
zgc:162619 (1)

Type

protein_coding_gene

Location

Chr: 9 Mapping Details/Browsers

Description

Predicted to enable double-stranded RNA binding activity and siRNA binding activity. Predicted to be involved in regulation of production of small RNA involved in gene silencing by RNA and siRNA processing. Predicted to act upstream of or within RNA-mediated gene silencing and phosphorylation. Predicted to be located in perinuclear region of cytoplasm. Predicted to be part of RISC complex and RISC-loading complex. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in dystonia 16. Orthologous to human PRKRA (protein activator of interferon induced protein kinase EIF2AK2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7151758 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With prkra Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
dystonia 16	Alliance	Dystonia 16	612067

Associated With prkra Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR007110	Immunoglobulin-like domain
Domain	IPR014720	Double-stranded RNA-binding domain
Domain	IPR032478	Staufen, C-terminal
Family	IPR051247	RISC Loading Complex Component