Gene
mast2
- ID
- ZDB-GENE-050309-150
- Name
- microtubule associated serine/threonine kinase 2
- Symbol
- mast2 Nomenclature History
- Previous Names
-
- im:7150634
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in cytoskeleton organization and intracellular signal transduction. Predicted to act upstream of or within protein phosphorylation. Predicted to be located in cytoplasm. Predicted to be active in microtubule cytoskeleton. Orthologous to human MAST2 (microtubule associated serine/threonine kinase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa489 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa7584 | Allele with one point mutation | Unknown | Missense | ENU | |
| sa8985 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa11672 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa20733 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa26772 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa26773 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa31517 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa33890 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa40724 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR000961 | AGC-kinase, C-terminal |
| Domain | IPR001478 | PDZ domain |
| Domain | IPR015022 | Microtubule-associated serine/threonine-protein kinase, pre-PK domain |
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Domain Details Per Protein
| Protein | Additional Resources | Length | AGC-kinase, C-terminal | Microtubule-associated serine/threonine-protein kinase, catalytic domain | Microtubule-associated serine/threonine-protein kinase, pre-PK domain | Microtubule-associated serine/threonine-protein kinase, pre-PK domain superfamily | PDZ domain | PDZ domain 6 | PDZ superfamily | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site | Serine/threonine-protein kinases, AGC |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:E7F723 | InterPro | 1934 | |||||||||||
| UniProtKB:A0A8M1PUY5 | InterPro | 1927 | |||||||||||
| UniProtKB:A0A8M9PYQ6 | InterPro | 1823 | |||||||||||
| UniProtKB:A0A8M9PZC4 | InterPro | 1823 | |||||||||||
| UniProtKB:A0A8M9P9A2 | InterPro | 1635 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-175H18 | ZFIN Curated Data | |
| Contained in | BAC | CH211-232J20 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-3E8 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-87O12 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7150634 | Thisse et al., 2004 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_009302496 (1) | 11258 nt | ||
| Genomic | RefSeq:NW_018394654 (1) | 354480 nt | ||
| Polypeptide | UniProtKB:E7F723 (1) | 1934 aa |
- Comparative Orthology
- Alliance
- Garcia-Concejo, A., Larhammar, D. (2021) Protein kinase C family evolution in jawed vertebrates. Developmental Biology. 479:77-90
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Giousoh, A., Vaz, R., Bryson-Richardson, R.J., Whisstock, J.C., Verkade, H., Bird, P.I. (2015) Bone morphogenetic protein/retinoic acid inducible neural-specific protein (brinp) expression during Danio rerio development. Gene expression patterns : GEP. 18(1-2):37-43
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