Gene
itsn2b
- ID
- ZDB-GENE-050309-102
- Name
- intersectin 2b
- Symbol
- itsn2b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable calcium ion binding activity and guanyl-nucleotide exchange factor activity. Predicted to be involved in positive regulation of Rho protein signal transduction. Predicted to act upstream of or within endocytosis. Predicted to be located in cytoplasm. Orthologous to human ITSN2 (intersectin 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7149072 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR018247 | EF-Hand 1, calcium-binding site |
| Domain | IPR000008 | C2 domain |
| Domain | IPR000219 | Dbl homology domain |
| Domain | IPR000261 | EH domain |
| Domain | IPR001452 | SH3 domain |
| Domain | IPR001849 | Pleckstrin homology domain |
| Domain | IPR002048 | EF-hand domain |
| Domain | IPR035740 | Intersectin-2, fourth SH3 domain |
| Family | IPR051480 | Endocytic & GEF Adapter |
| Homologous_superfamily | IPR011992 | EF-hand domain pair |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
| Homologous_superfamily | IPR035892 | C2 domain superfamily |
| Homologous_superfamily | IPR035899 | Dbl homology (DH) domain superfamily |
| Homologous_superfamily | IPR036028 | SH3-like domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | C2 domain | C2 domain superfamily | Dbl homology (DH) domain superfamily | Dbl homology domain | EF-Hand 1, calcium-binding site | EF-hand domain | EF-hand domain pair | EH domain | Endocytic & GEF Adapter | Intersectin-2, fourth SH3 domain | PH-like domain superfamily | Pleckstrin homology domain | SH3 domain | SH3-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q58EM8 | InterPro | 745 | ||||||||||||||
| UniProtKB:A0A8M2B5Q5 | InterPro | 1837 | ||||||||||||||
| UniProtKB:F1R0Z9 | InterPro | 1741 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
itsn2b-201
(1)
|
Ensembl | 6,492 nt |
Interactions and Pathways
No data available
Plasmids
No data available