Gene

baxb

ID
ZDB-GENE-050227-21
Name
BCL2 associated X, apoptosis regulator b
Symbol
baxb Nomenclature History
Previous Names
  • zBax2 (1)
  • zgc:112983 (1)
Type
protein_coding_gene
Location
Chr: 3 Mapping Details/Browsers
Description
Predicted to have protein heterodimerization activity and protein homodimerization activity. Involved in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process. Predicted to localize to mitochondrial outer membrane. Is expressed in eye; gut; heart; kidney; and ovary. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; ataxia telangiectasia; colon adenocarcinoma; and colorectal cancer. Orthologous to human BAX (BCL2 associated X, apoptosis regulator).
Genome Resources
Note
None
Expression
All Expression Data
5 figures from 5 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With baxb Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
acute lymphoblastic leukemia Alliance T-cell acute lymphoblastic leukemia, somatic 613065
colorectal cancer Alliance Colorectal cancer, somatic 114500
Associated With baxb Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR002475 Bcl2-like
Family IPR013279 Apoptosis regulator, Bcl-X
Family IPR026298 Blc2 family
Homologous_superfamily IPR036834 Blc2-like superfamily
Domain Details Per Protein
Protein Length Apoptosis regulator, Bcl-X Bcl2-like Blc2 family Blc2-like superfamily
UniProtKB:F1QTZ0 207
UniProtKB:Q5EAR7 207
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations