Gene
baxb
- ID
- ZDB-GENE-050227-21
- Name
- BCL2 associated X, apoptosis regulator b
- Symbol
- baxb Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable channel activity. Acts upstream of or within positive regulation of apoptotic process. Predicted to be located in membrane. Predicted to be active in mitochondrial outer membrane. Is expressed in eye; gut; heart; kidney; and ovary. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; ataxia telangiectasia; colon adenocarcinoma; and colorectal cancer. Orthologous to human BAX (BCL2 associated X, apoptosis regulator).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 11 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| acute lymphoblastic leukemia | Alliance | T-cell acute lymphoblastic leukemia, somatic | 613065 |
| colorectal cancer | Alliance | Colorectal cancer, somatic | 114500 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Bcl-2, Bcl-2 homology region 1-3 | Bcl-2 family | Bcl2-like | Bcl-2-like superfamily |
|---|---|---|---|---|---|
|
UniProtKB:Q5EAR7
|
207 |
Interactions and Pathways
No data available
Plasmids
No data available