Gene

baxb

ID
ZDB-GENE-050227-21
Name
BCL2 associated X, apoptosis regulator b
Symbol
baxb Nomenclature History
Previous Names
  • zBax2 (1)
  • zgc:112983 (1)
Type
protein_coding_gene
Location
Chr: 3 Mapping Details/Browsers
Description
Predicted to have protein heterodimerization activity and protein homodimerization activity. Involved in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process. Predicted to localize to mitochondrial outer membrane. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; ataxia telangiectasia; colon adenocarcinoma; and colorectal cancer. Is expressed in eye; gut; heart; kidney; and ovary. Orthologous to human BAX (BCL2 associated X, apoptosis regulator).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
11 figures from 10 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With baxb Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Colorectal cancer, somatic 114500
T-cell acute lymphoblastic leukemia, somatic 613065
Associated With baxb Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR046371 Bcl-2, Bcl-2 homology region 1-3
Family IPR002475 Bcl2-like
Family IPR026298 Bcl-2 family
Homologous_superfamily IPR036834 Bcl-2-like superfamily
Domain Details Per Protein
Protein Length Bcl-2, Bcl-2 homology region 1-3 Bcl-2 family Bcl2-like Bcl-2-like superfamily
UniProtKB:Q5EAR7 207
Transcripts
Genome Browsers
Type Name Annotation Method Length (nt) Analysis
mRNA baxb-201 (1) Havana 1271 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations