Gene
dlg1b
- ID
- ZDB-GENE-050222-3
- Name
- discs large MAGUK scaffold protein 1b
- Symbol
- dlg1b Nomenclature History
- Previous Names
-
- dlg1l
- SAP-97B (1)
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable ionotropic glutamate receptor binding activity; phosphatase binding activity; and protein kinase binding activity. Predicted to be involved in several processes, including actin cytoskeleton organization; endothelial cell proliferation; and negative regulation of G1/S transition of mitotic cell cycle. Predicted to be located in anchoring junction; apical plasma membrane; and endoplasmic reticulum membrane. Predicted to be active in several cellular components, including basolateral plasma membrane; neuromuscular junction; and postsynaptic density membrane. Is expressed in retina; spinal cord; and tegmentum. Human ortholog(s) of this gene implicated in invasive ductal carcinoma. Orthologous to human DLG1 (discs large MAGUK scaffold protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu269 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la014997Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la014998Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la014999Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la023752Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la028829Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa1431 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa10085 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa15931 | Allele with one point mutation | Unknown | Premature Stop | ENU |
1 - 8 of 8
Show
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Disks large 1-like | Disks large homolog 1-4, PDZ-associated domain | Disks large homologue 1, N-terminal PEST domain | Guanylate kinase, conserved site | Guanylate kinase-like domain | Guanylate kinase/L-type calcium channel beta subunit | L27-1 | L27 domain | L27 domain superfamily | PDZ domain | PDZ superfamily | P-loop containing nucleoside triphosphate hydrolase | SH3 domain | SH3-like domain superfamily | Synaptic Scaffolding LAP/MAGUK Families |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q5PYH5 | InterPro | 827 | |||||||||||||||
| UniProtKB:A0A8M3AVI6 | InterPro | 955 | |||||||||||||||
| UniProtKB:A0A8M9QIS4 | InterPro | 763 | |||||||||||||||
| UniProtKB:A0A8M3AN11 | InterPro | 990 | |||||||||||||||
| UniProtKB:A0A8M3ANR6 | InterPro | 969 |
1 - 5 of 25 Show all
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-162E15 | ZFIN Curated Data | |
| Contained in | BAC | CH211-257P7 | ZFIN Curated Data | |
| Contained in | BAC | CH211-262K7 | ZFIN Curated Data | |
| Encodes | EST | eu269 | Thisse et al., 2005 |
1 - 4 of 4
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001012388 (1) | 2662 nt | ||
| Genomic | GenBank:AL807799 (2) | 175342 nt | ||
| Polypeptide | UniProtKB:A0A8M3AN11 (1) | 990 aa |
- Tu, J., Yu, S., Li, J., Ren, M., Zhang, Y., Luo, J., Sun, K., Lv, Y., Han, Y., Huang, Y., Ren, X., Jiang, T., Tang, Z., Williams, M.T.S., Lu, Q., Liu, M. (2022) Dhx38 regulates the maintenance and differentiation of erythro-myeloid progenitors and hematopoietic stem cells by alternative splicing. Development (Cambridge, England). 149(17)
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Meyer, M.P., Trimmer, J.S., Gilthorpe, J.D., and Smith, S.J. (2005) Characterization of zebrafish PSD-95 gene family members. Journal of neurobiology. 63(2):91-105
1 - 5 of 5
Show