ZFIN is now using GRCz12tu for Genomic Data
Gene
tle2b
- ID
- ZDB-GENE-050208-677
- Name
- TLE family member 2, transcriptional corepressor b
- Symbol
- tle2b Nomenclature History
- Previous Names
-
- si:dkey-42p8.3 (1)
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable transcription corepressor activity. Predicted to be involved in negative regulation of canonical Wnt signaling pathway. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Orthologous to several human genes including TLE2 (TLE family member 2, transcriptional corepressor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019775 | WD40 repeat, conserved site |
| Domain | IPR005617 | Groucho/TLE, N-terminal Q-rich domain |
| Family | IPR009146 | Groucho/transducin-like enhancer |
| Homologous_superfamily | IPR015943 | WD40/YVTN repeat-like-containing domain superfamily |
| Homologous_superfamily | IPR036322 | WD40-repeat-containing domain superfamily |
| Repeat | IPR001680 | WD40 repeat |
Domain Details Per Protein
| Protein | Additional Resources | Length | Groucho/TLE, N-terminal Q-rich domain | Groucho/transducin-like enhancer | WD40 repeat | WD40 repeat, conserved site | WD40-repeat-containing domain superfamily | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8N7TB78 | InterPro | 763 | ||||||
| UniProtKB:A0A8M2BHV2 | InterPro | 762 |
Interactions and Pathways
No data available
Plasmids
No data available