Gene
cfh
- ID
- ZDB-GENE-050208-661
- Name
- complement factor H
- Symbol
- cfh Nomenclature History
- Previous Names
-
- im:7147412
- si:ch211-207o17.2
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable fumarate hydratase activity. Is expressed in several structures, including digestive system; eye; fin; gill; and heart. Human ortholog(s) of this gene implicated in several diseases, including atypical hemolytic-uremic syndrome; eye disease (multiple); hemolytic-uremic syndrome; lupus nephritis; and systemic lupus erythematosus. Orthologous to several human genes including CFH (complement factor H).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7147412 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| age related macular degeneration 4 | Alliance | {Macular degeneration, age-related, 4} | 610698 |
| basal laminar drusen | Alliance | Basal laminar drusen | 126700 |
| Complement factor H deficiency | 609814 | ||
| {Hemolytic uremic syndrome, atypical, susceptibility to, 1} | 235400 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Complement System Regulators and Virion Entry Mediators | Sushi/SCR/CCP domain | Sushi/SCR/CCP superfamily |
|---|---|---|---|---|---|
| UniProtKB:E2FHP4 | InterPro | 901 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-207O17 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7147412 | Thisse et al., 2004 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001199190 (1) | 2925 nt | ||
| Genomic | GenBank:BX005398 (1) | 209859 nt | ||
| Polypeptide | UniProtKB:E2FHP4 (1) | 901 aa |
- Deng, Y., Han, X., Chen, H., Zhao, C., Chen, Y., Zhou, J., de The, H., Zhu, J., Yuan, H. (2023) Ypel5 regulates liver development and function in zebrafish. Journal of molecular cell biology. 15(3):
- Niksirat, H., Siino, V., Steinbach, C., Levander, F. (2021) High-Resolution Proteomic Profiling Shows Sexual Dimorphism in Zebrafish Heart-Associated Proteins. Journal of Proteome Research. 20(8):4075-4088
- Boswell, M., Boswell, W., Lu, Y., Savage, M., Walter, R.B. (2020) Deconvoluting Wavelengths Leading to Fluorescent Light Induced Inflammation and Cellular Stress in Zebrafish (Danio rerio). Scientific Reports. 10:3321
- Jia, Z., Zhao, C., Wang, M., Zhao, X., Zhang, W., Han, T., Xia, Q., Han, Z., Lin, R., Li, X. (2019) Hepatotoxicity assessment of Rhizoma Paridis in adult zebrafish through proteomes and metabolome. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 121:109558
- Danilova, N., Wilkes, M., Bibikova, E., Youn, M.Y., Sakamoto, K.M., Lin, S. (2018) Innate immune system activation in zebrafish and cellular models of Diamond Blackfan Anemia. Scientific Reports. 8:5165
- Deng, S., Jia, P.P., Zhang, J.H., Junaid, M., Niu, A., Ma, Y.B., Fu, A., Pei, D.S. (2018) Transcriptomic response and perturbation of toxicity pathways in zebrafish larvae after exposure to graphene quantum dots (GQDs). Journal of hazardous materials. 357:146-158
- Mesquita, S.R., van Drooge, B.L., Oliveira, E., Grimalt, J.O., Barata, C., Vieira, N., Guimarães, L., Piña, B. (2015) Differential embryotoxicity of the organic pollutants in rural and urban air particles. Environmental pollution (Barking, Essex : 1987). 206:535-542
- Wu, J., Li, H., and Zhang, S. (2012) Regulator of complement activation (RCA) group 2 gene cluster in zebrafish: identification, expression, and evolution. Functional & integrative genomics. 12(2):367-377
- Sun, G., Li, H., Wang, Y., Zhang, B., and Zhang, S. (2010) Zebrafish complement factor H and its related genes: identification, evolution, and expression. Functional & integrative genomics. 10(4):577-587
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