Gene

sipa1l2

ID

ZDB-GENE-050208-66

Name

signal-induced proliferation-associated 1 like 2

Symbol

sipa1l2 Nomenclature History

Previous Names

im:7137555 (1)
si:dkey-77m16.2

Type

protein_coding_gene

Location

Chr: 11 Mapping Details/Browsers

Description

Predicted to enable GTPase activator activity. Predicted to be involved in activation of GTPase activity. Predicted to act upstream of or within regulation of small GTPase mediated signal transduction. Predicted to be active in cytoplasm. Is expressed in brain; solid lens vesicle; and somite. Orthologous to human SIPA1L2 (signal induced proliferation associated 1 like 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7137555 (12 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With sipa1l2 Human Ortholog

No data available

Associated With sipa1l2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000331	Rap/Ran-GAP domain
Domain	IPR001478	PDZ domain
Domain	IPR021818	Signal-induced proliferation-associated 1-like protein, C-terminal
Family	IPR050989	Rap1/Ran GTPase-activating
Homologous_superfamily	IPR035974	Rap/Ran-GAP superfamily
Homologous_superfamily	IPR036034	PDZ superfamily

Domain Details Per Protein

Protein	Length	PDZ domain	PDZ superfamily	Rap1/Ran GTPase-activating	Rap/Ran-GAP domain	Rap/Ran-GAP superfamily	Signal-induced proliferation-associated 1-like protein, C-terminal
UniProtKB:A0A2R8QKB1 InterPro	1689
UniProtKB:E7FE99 InterPro	1672

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	sipa1l2-201 (1) Ensembl	Ensembl	6,697 nt	Select Tool ZFIN BLAST
mRNA	sipa1l2-202 (1) Ensembl	Ensembl	9,692 nt	Select Tool ZFIN BLAST
mRNA	sipa1l2-203 (1) Ensembl	Ensembl	6,342 nt	Select Tool ZFIN BLAST
mRNA	sipa1l2-204 (1) Ensembl	Ensembl	9,875 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance

Citations