Gene
sirt7
- ID
- ZDB-GENE-050208-612
- Name
- sirtuin 7
- Symbol
- sirt7 Nomenclature History
- Previous Names
-
- si:ch211-258l4.6 (1)
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable NAD+ binding activity and NAD-dependent protein lysine deacylase activity. Acts upstream of or within antiviral innate immune response; hematopoietic progenitor cell differentiation; and response to hypoxia. Predicted to be active in chromatin and nucleus. Is expressed in retina. Orthologous to human SIRT7 (sirtuin 7).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu987 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Huang et al., 2013
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ihblqs4 | Allele with one deletion | Exon 2 | Unknown | CRISPR | |
| ihblqs7 | Allele with one deletion | Exon 2 | Unknown | CRISPR | |
| ihblqs44 | Allele with one deletion | Exon 2 | Unknown | CRISPR | |
| sa24226 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa30735 | Allele with one point mutation | Unknown | Premature Stop | ENU |
1 - 5 of 5
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | DHS-like NAD/FAD-binding domain superfamily | NAD-dependent sirtuin protein deacylases | Sirtuin family | Sirtuin family, catalytic core domain |
|---|---|---|---|---|---|---|
| UniProtKB:A0A2R8QUG9 | InterPro | 405 |
1 - 1 of 1
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available