Gene
gna11a
- ID
- ZDB-GENE-050208-597
- Name
- guanine nucleotide binding protein (G protein), alpha 11a (Gq class)
- Symbol
- gna11a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable several functions, including G-protein beta/gamma-subunit complex binding activity; GTPase activator activity; and GTPase activity. Predicted to be involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be part of heterotrimeric G-protein complex. Predicted to be active in cytoplasm. Is expressed in barbel; brain; gill; lip; and sensory system. Human ortholog(s) of this gene implicated in autosomal dominant hypocalcemia 2 and familial hypocalciuric hypercalcemia 2. Orthologous to human GNA11 (G protein subunit alpha 11).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant hypocalcemia 2 | Alliance | Hypocalcemia, autosomal dominant 2 | 615361 |
| familial hypocalciuric hypercalcemia 2 | Alliance | Hypocalciuric hypercalcemia, type II | 145981 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR000654 | G-protein alpha subunit, group Q |
| Family | IPR001019 | Guanine nucleotide binding protein (G-protein), alpha subunit |
| Homologous_superfamily | IPR011025 | G protein alpha subunit, helical insertion |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
Domain Details Per Protein
| Protein | Additional Resources | Length | G-protein alpha subunit, group Q | G protein alpha subunit, helical insertion | Guanine nucleotide binding protein (G-protein), alpha subunit | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PVA9 | InterPro | 270 | ||||
| UniProtKB:B3DI16 | InterPro | 359 | ||||
| UniProtKB:A0A0R4IEQ0 | InterPro | 400 | ||||
| UniProtKB:F6PAM1 | InterPro | 359 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
gna11a-201
(1)
|
Ensembl | 1,139 nt | ||
| mRNA |
gna11a-202
(1)
|
Ensembl | 1,199 nt | ||
| mRNA |
gna11a-203
(1)
|
Ensembl | 1,203 nt |
Interactions and Pathways
No data available
Plasmids
No data available