Gene
pdgfba
- ID
- ZDB-GENE-050208-525
- Name
- platelet-derived growth factor beta polypeptide a
- Symbol
- pdgfba Nomenclature History
- Previous Names
-
- pdgfb
- sb:eu1033
- si:ch211-79m20.1
- si:dkey-261d11.1
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable platelet-derived growth factor receptor binding activity. Acts upstream of or within several processes, including pericyte cell differentiation; regulation of DNA replication; and vasculature development. Predicted to be located in membrane. Predicted to be active in extracellular space. Is expressed in cardiovascular system; diencephalon; floor plate; head; and liver. Human ortholog(s) of this gene implicated in several diseases, including basal ganglia calcification; clear cell renal cell carcinoma; dermatofibrosarcoma protuberans; familial meningioma; and high grade glioma (multiple). Orthologous to human PDGFB (platelet derived growth factor subunit B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 19 figures from 13 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu1033 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Ando et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-pdgfba | Stratman et al., 2020 | |
| CRISPR2-pdgfba | Ando et al., 2021 | |
| MO1-pdgfba | N/A | Kartopawiro et al., 2014 |
| MO2-pdgfba | N/A | Kartopawiro et al., 2014 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| basal ganglia calcification | Alliance | Basal ganglia calcification, idiopathic, 5 | 615483 |
| Meningioma, SIS-related | 607174 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cystine-knot cytokine | PDGF/VEGF domain | Platelet-derived growth factor, conserved site |
|---|---|---|---|---|---|
| UniProtKB:A0A8M9Q3E7 | InterPro | 463 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
pdgfba-201
(1)
|
Ensembl | 1,736 nt | ||
| mRNA |
pdgfba-202
(1)
|
Ensembl | 1,195 nt | ||
| mRNA |
pdgfba-203
(1)
|
Ensembl | 2,516 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(UAS:dnpdgfrb-YFP) |
|
| 1 | (4) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-79M20 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-261D11 | ZFIN Curated Data | |
| Encodes | EST | eu1033 | Thisse et al., 2005 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001423262 (1) | 5440 nt | ||
| Genomic | GenBank:AL929274 (2) | 169459 nt | ||
| Polypeptide | UniProtKB:A0A8M9Q3E7 (1) | 463 aa |
- Ribeiro, A., Rebocho da Costa, M., de Sena-Tomás, C., Rodrigues, E.C., Quitéria, R., Maçarico, T., Rosa Santos, S.C., Saúde, L. (2023) Development and repair of blood vessels in the zebrafish spinal cord. Open Biology. 13:230103230103
- Ando, K., Shih, Y.H., Ebarasi, L., Grosse, A., Portman, D., Chiba, A., Mattonet, K., Gerri, C., Stainier, D.Y.R., Mochizuki, N., Fukuhara, S., Betsholtz, C., Lawson, N.D. (2021) Conserved and context-dependent roles for pdgfrb signaling during zebrafish vascular mural cell development. Developmental Biology. 479:11-22
- Mi, X., Li, Z., Yan, J., Li, Y., Zheng, J., Zhaung, Z., Yang, W., Gong, L., Shi, J. (2020) Activation of HIF-1 signaling ameliorates liver steatosis in zebrafish atp7b deficiency (Wilson's disease) models. Biochimica et biophysica acta. Molecular basis of disease. 1866(10):165842
- Saito, Y., Yamaguchi, A., Nakamura, S., Okuyoshi, H., Shimazawa, M., Hara, H. (2020) Contribution of platelet-derived growth factor signaling to retina regeneration in zebrafish. Neuroscience letters. 727:134930
- Stratman, A.N., Burns, M.C., Farrelly, O.M., Davis, A.E., Li, W., Pham, V.N., Castranova, D., Yano, J.J., Goddard, L.M., Nguyen, O., Galanternik, M.V., Bolan, T.J., Kahn, M.L., Mukouyama, Y.S., Weinstein, B.M. (2020) Chemokine mediated signalling within arteries promotes vascular smooth muscle cell recruitment. Communications biology. 3:734
- Tsata, V., Möllmert, S., Schweitzer, C., Kolb, J., Möckel, C., Böhm, B., Rosso, G., Lange, C., Lesche, M., Hammer, J., Kesavan, G., Beis, D., Guck, J., Brand, M., Wehner, D. (2020) A switch in pdgfrb+ cell-derived ECM composition prevents inhibitory scarring and promotes axon regeneration in the zebrafish spinal cord. Developmental Cell. 56(4):509-524.e9
- Tu, J., Liu, X., Jia, H., Reilly, J., Yu, S., Cai, C., Liu, F., Lv, Y., Huang, Y., Lu, Z., Han, S., Jiang, T., Shu, X., Wu, X., Tang, Z., Lu, Q., Liu, M. (2020) The chromatin remodeler Brg1 is required for formation and maintenance of hematopoietic stem cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 34(9):11997-12008
- DeRossi, C., Bambino, K., Morrison, J., Sakarin, I., Villacorta-Martin, C., Zhang, C., Ellis, J.L., Fiel, M.I., Ybanez, M., Lee, Y.A., Huang, K.L., Yin, C., Sakaguchi, T.F., Friedman, S.L., Villanueva, A., Chu, J. (2019) Mannose Phosphate Isomerase and Mannose Regulate Hepatic Stellate Cell Activation and Fibrosis in Zebrafish and Humans. Hepatology (Baltimore, Md.). 70(6):2107-2122
- Watterston, C., Zeng, L., Onabadejo, A., Childs, S.J. (2019) MicroRNA26 attenuates vascular smooth muscle maturation via endothelial BMP signalling. PLoS Genetics. 15:e1008163
- Oosterhof, N., Kuil, L.E., van der Linde, H.C., Burm, S.M., Berdowski, W., van Ijcken, W.F.J., van Swieten, J.C., Hol, E.M., Verheijen, M.H.G., van Ham, T.J. (2018) Colony-Stimulating Factor 1 Receptor (CSF1R) Regulates Microglia Density and Distribution, but Not Microglia Differentiation In Vivo. Cell Reports. 24:1203-1217.e6
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