bap1

ID

ZDB-GENE-050208-492

Name

BRCA1 associated deubiquitinase 1

Symbol

bap1 Nomenclature History

Previous Names

si:dkey-42i9.9

Type

protein_coding_gene

Location

Chr: 22 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable chromatin binding activity and cysteine-type deubiquitinase activity. Acts upstream of or within Notch signaling pathway and cranial skeletal system development. Predicted to be located in nucleus. Predicted to be part of PR-DUB complex. Predicted to be active in cytoplasm. Is expressed in nervous system; pectoral fin; and post-vent region. Human ortholog(s) of this gene implicated in basal cell carcinoma; extrahepatic bile duct adenocarcinoma; and uveal melanoma. Orthologous to human BAP1 (BRCA1 associated deubiquitinase 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu310 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With bap1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
uveal melanoma	Alliance	{Uveal melanoma, susceptibility to, 2}	606661
		Kury-Isidor syndrome	619762
		Tumor predisposition syndrome 1	614327

Associated With bap1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001578	Peptidase C12, ubiquitin carboxyl-terminal hydrolase
Domain	IPR041507	Peptidase C12, C-terminal domain
Homologous_superfamily	IPR036959	Peptidase C12, ubiquitin carboxyl-terminal hydrolase superfamily
Homologous_superfamily	IPR038765	Papain-like cysteine peptidase superfamily