Gene
pth2rb
- ID
- ZDB-GENE-050208-334
- Name
- parathyroid hormone 2 receptor b
- Symbol
- pth2rb Nomenclature History
- Previous Names
-
- si:dkeyp-4h4.1
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable G protein-coupled peptide receptor activity; parathyroid hormone receptor activity; and peptide hormone binding activity. Predicted to be involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway. Predicted to act upstream of or within G protein-coupled receptor signaling pathway and cell surface receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human PTH2R (parathyroid hormone 2 receptor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la028392Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa1706 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa1961 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017983 | GPCR, family 2, secretin-like, conserved site |
| Domain | IPR001879 | GPCR, family 2, extracellular hormone receptor domain |
| Domain | IPR017981 | GPCR, family 2-like, 7TM |
| Family | IPR000832 | GPCR, family 2, secretin-like |
| Family | IPR050332 | G-protein coupled receptor 2 |
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Domain Details Per Protein
| Protein | Additional Resources | Length | GPCR, family 2, extracellular hormone receptor domain | GPCR family 2, extracellular hormone receptor domain superfamily | GPCR, family 2-like, 7TM | GPCR, family 2, secretin-like | GPCR, family 2, secretin-like, conserved site | G-protein coupled receptor 2 |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1RBM7 | InterPro | 600 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
pth2rb-201
(1)
|
Ensembl | 1,997 nt | ||
| mRNA |
si:dkeyp-4h4.1-202
(1)
|
Ensembl | 1,526 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-4H4 | ZFIN Curated Data | |
| Contained in | BAC | RP71-1N18 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_017353489 (1) | |||
| Genomic | GenBank:AL645755 | 141779 nt | ||
| Polypeptide | UniProtKB:F1RBM7 (1) | 600 aa |
- Comparative Orthology
- Alliance
- Zhang, S., Wang, X., Yang, Q., Xia, Q., Zhao, Y., Zheng, X., Zhang, Y., Liu, K. (2023) Isopropyl 3-(3,4-dihydroxyphenyl)-2-hydroxypropanoate plays an anti-hypoxic role through regulating neuroactive ligand-receptor interaction signaling pathway in larval zebrafish. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 161:114570114570
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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