ZFIN is now using GRCz12tu for Genomic Data
Gene
phip
- ID
- ZDB-GENE-050208-261
- Name
- PHIP subunit of CUL4-Ring ligase complex
- Symbol
- phip Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to be involved in negative regulation of apoptotic process; positive regulation of DNA-templated transcription; and regulation of signal transduction. Predicted to be located in nucleus. Is expressed in nervous system and notochord. Human ortholog(s) of this gene implicated in intellectual disability. Orthologous to human PHIP (PHIP subunit of CUL4-Ring ligase complex).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7147010 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Chung-Jansen syndrome | 617991 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018359 | Bromodomain, conserved site |
| Conserved_site | IPR019775 | WD40 repeat, conserved site |
| Domain | IPR001487 | Bromodomain |
| Domain | IPR057451 | BRWD/PHIP, ancillary-like domain |
| Domain | IPR057452 | BRWD/PHIP, N-terminal domain |
| Family | IPR052060 | Bromodomain and WD repeat-containing |
| Homologous_superfamily | IPR015943 | WD40/YVTN repeat-like-containing domain superfamily |
| Homologous_superfamily | IPR036322 | WD40-repeat-containing domain superfamily |
| Homologous_superfamily | IPR036427 | Bromodomain-like superfamily |
| Repeat | IPR001680 | WD40 repeat |
Domain Details Per Protein
| Protein | Additional Resources | Length | Bromodomain | Bromodomain and WD repeat-containing | Bromodomain, conserved site | Bromodomain-like superfamily | BRWD/PHIP, ancillary-like domain | BRWD/PHIP, N-terminal domain | WD40 repeat | WD40 repeat, conserved site | WD40-repeat-containing domain superfamily | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3B6B2 | InterPro | 1806 | ||||||||||
| UniProtKB:A0A8M9PE61 | InterPro | 1806 | ||||||||||
| UniProtKB:A0A8M2B991 | InterPro | 1635 | ||||||||||
| UniProtKB:A0A8M3AN51 | InterPro | 1807 | ||||||||||
| UniProtKB:A0A8M9PQW8 | InterPro | 1805 | ||||||||||
| UniProtKB:A0AC58IM31 | InterPro | 1635 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers