Gene
phip
- ID
- ZDB-GENE-050208-261
- Name
- PHIP subunit of CUL4-Ring ligase complex
- Symbol
- phip Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to be involved in cytoskeleton organization; regulation of cell shape; and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human PHIP (pleckstrin homology domain interacting protein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7147010 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la028545Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa13928 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa24372 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa29964 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa31091 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa32454 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa32455 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa39419 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-phip | LaCoursiere et al., 2024 | |
| CRISPR2-phip | LaCoursiere et al., 2024 | |
| MO1-phip | N/A | Huang et al., 2013 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Chung-Jansen syndrome | 617991 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018359 | Bromodomain, conserved site |
| Conserved_site | IPR019775 | WD40 repeat, conserved site |
| Domain | IPR001487 | Bromodomain |
| Family | IPR052060 | Bromodomain and WD repeat-containing |
| Homologous_superfamily | IPR015943 | WD40/YVTN repeat-like-containing domain superfamily |
| Homologous_superfamily | IPR036322 | WD40-repeat-containing domain superfamily |
| Homologous_superfamily | IPR036427 | Bromodomain-like superfamily |
| Repeat | IPR001680 | WD40 repeat |
Domain Details Per Protein
| Protein | Additional Resources | Length | Bromodomain | Bromodomain and WD repeat-containing | Bromodomain, conserved site | Bromodomain-like superfamily | WD40 repeat | WD40 repeat, conserved site | WD40-repeat-containing domain superfamily | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3B6B2 | InterPro | 1806 | ||||||||
| UniProtKB:A0A8M9PE61 | InterPro | 1806 | ||||||||
| UniProtKB:A0A8M2B991 | InterPro | 1635 | ||||||||
| UniProtKB:A0A8M3AN51 | InterPro | 1807 | ||||||||
| UniProtKB:A0A8M9PQW8 | InterPro | 1805 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-241O6 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-261L7 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7147010 | Thisse et al., 2004 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_009297004 (1) | 9704 nt | ||
| Genomic | GenBank:BX322566 (1) | 203127 nt | ||
| Polypeptide | UniProtKB:A0A8M3AN51 (1) | 1807 aa |
- LaCoursiere, C.M., Ullmann, J.F.P., Koh, H.Y., Turner, L., Baker, C.M., Robens, B., Shao, W., Rotenberg, A., McGraw, C.M., Poduri, A.H. (2024) Zebrafish models of candidate human epilepsy-associated genes provide evidence of hyperexcitability. iScience. 27:110172110172
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Huang, H.T., Kathrein, K.L., Barton, A., Gitlin, Z., Huang, Y.H., Ward, T.P., Hofmann, O., Dibiase, A., Song, A., Tyekucheva, S., Hide, W., Zhou, Y., and Zon, L.I. (2013) A network of epigenetic regulators guides developmental haematopoiesis in vivo. Nature cell biology. 15(12):1516-1525
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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