| ZFIN ID: ZDB-GENE-050208-221 |
| Gene Name: | aggrecan a | |||||||||||||
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| Gene Symbol: | acana Nomenclature History |
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Attributions
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| Previous Names: | agca, agc1, im:7146049 | |||||||||||||
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| Gene Type: | protein_coding_gene | |||||||||||||
| Location: | Chr: 7 Mapping Details/Browsers | |||||||||||||
| Description: | Predicted to have calcium ion binding activity and hyaluronic acid binding activity. Involved in outflow tract morphogenesis. Predicted to localize to the extracellular matrix. Is expressed in bulbus arteriosus; cranium; pectoral fin; and pharyngeal arch 3-7. Orthologous to human ACAN (aggrecan). | |||||||||||||
| Genome Resources: | Alliance (1), Gene:497505 (1), Ensembl(GRCz11):ENSDARG00000035891 (2) | |||||||||||||
| All Expression Data: | 9 figures from 9 publications |
| Directly Submitted Expression Data: | 1 figure (1 image) from Thisse et al., 2004 [IMAGE:7146049] |
| Wild-type Stages, Structures: | Zygote:1-cell (0.0h-0.75h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth) |
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| Allele | Type | Localization | Consequence | Mutagen | Suppliers |
|---|---|---|---|---|---|
| sa7281 | Point Mutation | Unknown | Premature Stop | ENU | |
| sa31591 | Point Mutation | Unknown | Splice Site | ENU |
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| sa40999 | Point Mutation | Unknown | Premature Stop | ENU |
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| Data: | 5 figures from Rambeau et al., 2017 |
| Observed in: |
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| osteochondritis dissecans | Alliance | Short stature and advanced bone age, with or without early-onset osteoarthritis and/or osteochondritis dissecans | 165800 |
| Spondyloepimetaphyseal dysplasia, aggrecan type | 612813 | ||
| ?Spondyloepiphyseal dysplasia, Kimberley type | 608361 |
| Ontology | GO Term |
|---|---|
| Biological Process | outflow tract morphogenesis (more) |
| Cellular Component | extracellular matrix (more) |
| Molecular Function | calcium ion binding (more) |
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| Type | Name | Length (nt) | Analysis | |
|---|---|---|---|---|
| mRNA |
acana-201
(1)
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6000 |
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| Browsers: NCBI, Ensembl, ZFIN |
| acana Contained in: | [BAC] DKEY-56P7 (1) (order this) |
| acana Encodes: | [EST] IMAGE:7146049 (1) (order this) |
| Type | Accession # | Length (bp/aa) | Analysis |
|---|---|---|---|
| RNA | RefSeq:XM_005166485 (1) | 6450 bp |
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| Genomic | GenBank:AL929208 (1) | 189608 bp | |
| Polypeptide | UniProtKB:F1QDA1 (1) | 1547 aa |
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| Sequence Clusters | UniGene:89851 (1) |
