Gene

acana

ID
ZDB-GENE-050208-221
Name
aggrecan a
Symbol
acana Nomenclature History
Previous Names
  • agca
  • agc1
  • im:7146049
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Predicted to enable calcium ion binding activity; carbohydrate binding activity; and hyaluronic acid binding activity. Acts upstream of or within outflow tract morphogenesis. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix. Is expressed in bulbus arteriosus; cranium; pectoral fin; and pharyngeal arch 3-7. Human ortholog(s) of this gene implicated in spondyloepiphyseal dysplasia Kimberley type. Orthologous to human ACAN (aggrecan).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
11 figures from 11 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
5 figures from Rambeau et al., 2017
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With acana Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
osteochondritis dissecans Alliance Short stature and advanced bone age, with or without early-onset osteoarthritis and/or osteochondritis dissecans 165800
spondyloepiphyseal dysplasia Kimberley type Alliance ?Spondyloepiphyseal dysplasia, Kimberley type 608361
Spondyloepimetaphyseal dysplasia, aggrecan type 612813
Associated With acana Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018378 C-type lectin, conserved site
Domain IPR000436 Sushi/SCR/CCP domain
Domain IPR000538 Link domain
Domain IPR000742 EGF-like domain
Domain IPR001304 C-type lectin-like
Domain IPR001881 EGF-like calcium-binding domain
Domain IPR003599 Immunoglobulin subtype
Domain IPR007110 Immunoglobulin-like domain
Domain IPR013106 Immunoglobulin V-set domain
Domain IPR033987 Aggrecan/versican, C-type lectin-like domain
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR016186 C-type lectin-like/link domain superfamily
Homologous_superfamily IPR016187 C-type lectin fold
Homologous_superfamily IPR035976 Sushi/SCR/CCP superfamily
Homologous_superfamily IPR036179 Immunoglobulin-like domain superfamily
Domain Details Per Protein
Protein Length Aggrecan/versican, C-type lectin-like domain C-type lectin, conserved site C-type lectin fold C-type lectin-like C-type lectin-like/link domain superfamily EGF-like calcium-binding domain EGF-like domain Immunoglobulin-like domain Immunoglobulin-like domain superfamily Immunoglobulin-like fold Immunoglobulin subtype Immunoglobulin V-set domain Link domain Sushi/SCR/CCP domain Sushi/SCR/CCP superfamily
UniProtKB:Q75ZI2 287
UniProtKB:E7F537 1509
UniProtKB:Q58EI4 172
UniProtKB:F1QDA1 1547
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations