ZFIN is now using GRCz12tu for Genomic Data
Gene
sorl1
- ID
- ZDB-GENE-050208-22
- Name
- sortilin-related receptor, L(DLR class) A repeats containing
- Symbol
- sorl1 Nomenclature History
- Previous Names
-
- im:7135957
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to be involved in post-Golgi vesicle-mediated transport; protein retention in Golgi apparatus; and protein targeting to lysosome. Predicted to act upstream of or within endocytosis. Predicted to be located in several cellular components, including cytoplasmic vesicle membrane; endoplasmic reticulum membrane; and extracellular region. Predicted to be active in Golgi apparatus and membrane. Is expressed in central nervous system; hatching gland; mesoderm; and somite. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human SORL1 (sortilin related receptor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7135957 (8 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR023415 | Low-density lipoprotein (LDL) receptor class A, conserved site |
| Domain | IPR003961 | Fibronectin type III |
| Domain | IPR006581 | VPS10 |
| Domain | IPR031777 | Sortilin, C-terminal |
| Domain | IPR031778 | Sortilin, N-terminal |
| Family | IPR050310 | VPS10-related sortilin family receptors |
| Homologous_superfamily | IPR011042 | Six-bladed beta-propeller, TolB-like |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR015943 | WD40/YVTN repeat-like-containing domain superfamily |
| Homologous_superfamily | IPR036055 | LDL receptor-like superfamily |
| Homologous_superfamily | IPR036116 | Fibronectin type III superfamily |
| Repeat | IPR000033 | LDLR class B repeat |
| Repeat | IPR002172 | Low-density lipoprotein (LDL) receptor class A repeat |
Domain Details Per Protein
| Protein | Additional Resources | Length | Fibronectin type III | Fibronectin type III superfamily | Immunoglobulin-like fold | LDLR class B repeat | LDL receptor-like superfamily | Low-density lipoprotein (LDL) receptor class A, conserved site | Low-density lipoprotein (LDL) receptor class A repeat | Six-bladed beta-propeller, TolB-like | Sortilin, C-terminal | Sortilin, N-terminal | VPS10 | VPS10-related sortilin family receptors | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2B3P2 | InterPro | 2211 | |||||||||||||
| UniProtKB:X1WHE3 | InterPro | 2213 | |||||||||||||
| UniProtKB:A0AB32T1T4 | InterPro | 2211 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers