Gene

sorl1

ID
ZDB-GENE-050208-22
Name
sortilin-related receptor, L(DLR class) A repeats containing
Symbol
sorl1 Nomenclature History
Previous Names
  • im:7135957
Type
protein_coding_gene
Location
Chr: 15 Mapping Details/Browsers
Description
Predicted to be involved in post-Golgi vesicle-mediated transport; protein retention in Golgi apparatus; and protein targeting to lysosome. Predicted to act upstream of or within endocytosis. Predicted to be located in several cellular components, including Golgi membrane; cytoplasmic vesicle membrane; and endoplasmic reticulum membrane. Predicted to be active in Golgi apparatus and membrane. Is expressed in central nervous system; hatching gland; mesoderm; and somite. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human SORL1 (sortilin related receptor 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
8 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Barthelson et al., 2020
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With sorl1 Human Ortholog
No data available
Associated With sorl1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
Domain IPR003961 Fibronectin type III
Domain IPR006581 VPS10
Domain IPR031777 Sortilin, C-terminal
Domain IPR031778 Sortilin, N-terminal
Homologous_superfamily IPR011042 Six-bladed beta-propeller, TolB-like
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR015943 WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily IPR036055 LDL receptor-like superfamily
Homologous_superfamily IPR036116 Fibronectin type III superfamily
Repeat IPR000033 LDLR class B repeat
Repeat IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
Domain Details Per Protein
Protein Length Fibronectin type III Fibronectin type III superfamily Immunoglobulin-like fold LDLR class B repeat LDL receptor-like superfamily Low-density lipoprotein (LDL) receptor class A, conserved site Low-density lipoprotein (LDL) receptor class A repeat Six-bladed beta-propeller, TolB-like Sortilin, C-terminal Sortilin, N-terminal VPS10 WD40/YVTN repeat-like-containing domain superfamily
UniProtKB:X1WHE3 2213
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations