Gene

mecom

ID
ZDB-GENE-050208-123
Name
MDS1 and EVI1 complex locus
Symbol
mecom Nomenclature History
Previous Names
  • evi1
  • im:7140716
  • prdm3 (1)
Type
protein_coding_gene
Location
Chr: 15 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including embryonic cranial skeleton morphogenesis; endothelial to hematopoietic transition; and pronephric nephron development. Predicted to localize to nucleus. Is expressed in several structures, including brain; dorsal aorta; head; mesoderm; and pronephros. Human ortholog(s) of this gene implicated in myeloid neoplasm. Orthologous to human MECOM (MDS1 and EVI1 complex locus).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
21 figures from 12 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
13 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With mecom Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Radioulnar synostosis with amegakaryocytic thrombocytopenia 2 616738
Associated With mecom Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR013087 Zinc finger C2H2-type
Homologous_superfamily IPR036236 Zinc finger C2H2 superfamily
Domain Details Per Protein
Protein Length Zinc finger C2H2 superfamily Zinc finger C2H2-type
UniProtKB:A0A2R8QF28 192
UniProtKB:A5HML2 603
UniProtKB:A5XCD7 299
UniProtKB:F1Q834 766
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations