Gene
glsa
- ID
- ZDB-GENE-050204-3
- Name
- glutaminase a
- Symbol
- glsa Nomenclature History
- Previous Names
-
- glsl
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable glutaminase activity. Predicted to be involved in glutamate biosynthetic process and glutamine catabolic process. Predicted to act upstream of or within glutamine metabolic process. Is expressed in brain; pectoral fin; and swim bladder. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 71. Orthologous to human GLS (glutaminase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| developmental and epileptic encephalopathy 71 | Alliance | Developmental and epileptic encephalopathy 71 | 618328 |
| CASGID syndrome | 618339 | ||
| Global developmental delay, progressive ataxia, and elevated glutamine | 618412 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Ankyrin repeat | Ankyrin repeat-containing domain superfamily | Beta-lactamase/transpeptidase-like | Glutaminase | Glutaminase, EF-hand domain |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2B8I6 | InterPro | 589 | |||||
| UniProtKB:Q1LWI2 | InterPro | 591 | |||||
| UniProtKB:A0A8M3AUM0 | InterPro | 519 | |||||
| UniProtKB:A0A8M9PRT8 | InterPro | 325 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-84A8 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001045044 (1) | 1859 nt | ||
| Genomic | GenBank:BX548072 (1) | 188936 nt | ||
| Polypeptide | UniProtKB:Q1LWI2 (1) | 591 aa |
- Jia, P.P., Chandrajith, R., Junaid, M., Li, T.Y., Li, Y.Z., Wei, X.Y., Liu, L., Pei, D.S. (2023) Elucidating environmental factors and their combined effects on CKDu in Sri Lanka using zebrafish. Environmental pollution (Barking, Essex : 1987). 332:121967
- Shi, Z., Liang, X., Zhao, Y., Liu, W., Martyniuk, C.J. (2022) Neurotoxic effects of synthetic phenolic antioxidants on dopaminergic, serotoninergic, and GABAergic signaling in larval zebrafish (Danio rerio). The Science of the total environment. 830:154688
- Wang, X., Liao, Q., Chen, H., Gong, G., Siu, S.W.I., Chen, Q., Kam, H., Ung, C.O.L., Cheung, K.K., Rádis-Baptista, G., Wong, C.T.T., Lee, S.M. (2021) Toxic Peptide From Palythoa caribaeorum Acting on the TRPV1 Channel Prevents Pentylenetetrazol-Induced Epilepsy in Zebrafish Larvae. Frontiers in pharmacology. 12:763089
- Cao, Z., Su, M., Wang, H., Zhou, L., Meng, Z., Xiong, G., Liao, X., Lu, H. (2020) Carboxyl graphene oxide nanoparticles induce neurodevelopmental defects and locomotor disorders in zebrafish larvae. Chemosphere. 270:128611
- Cheng, B., Jiang, F., Su, M., Zhou, L., Zhang, H., Cao, Z., Liao, X., Xiong, G., Xiao, J., Liu, F., Lu, H. (2020) Effects of lincomycin hydrochloride on the neurotoxicity of zebrafish. Ecotoxicology and environmental safety. 201:110725
- Gong, G., Chen, H., Kam, H., Chan, G., Tang, Y.X., Wu, M., Tan, H., Tse, Y.C., Xu, H.X., Lee, S.M. (2020) In Vivo Screening of Xanthones from Garcinia oligantha Identified Oliganthin H as a Novel Natural Inhibitor of Convulsions. Journal of natural products. 83(12):3706-3716
- Liu, S., Yu, M., Xie, X., Ru, Y., Ru, S. (2020) Carbofuran induces increased anxiety-like behaviors in female zebrafish (Danio rerio) through disturbing dopaminergic/norepinephrinergic system. Chemosphere. 253:126635
- Breuer, M., Guglielmi, L., Zielonka, M., Hemberger, V., Kölker, S., Okun, J.G., Hoffmann, G.F., Carl, M., Sauer, S.W., Opladen, T. (2019) QDPR homologues in Danio rerio regulate melanin synthesis, early gliogenesis, and glutamine homeostasis. PLoS One. 14:e0215162
- Wang, H., Meng, Z., Liu, F., Zhou, L., Su, M., Meng, Y., Zhang, S., Liao, X., Cao, Z., Lu, H. (2019) Characterization of boscalid-induced oxidative stress and neurodevelopmental toxicity in zebrafish embryos. Chemosphere. 238:124753
- Wang, H., Zhou, L., Meng, Z., Su, M., Zhang, S., Huang, P., Jiang, F., Liao, X., Cao, Z., Lu, H. (2019) Clethodim exposure induced development toxicity and behaviour alteration in early stages of zebrafish life. Environmental pollution (Barking, Essex : 1987). 255:113218
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