header logo image header logo text
Downloads Login
Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-050201-4
Gene Name: fibroblast growth factor 23
Gene Symbol: fgf23    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Name:

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 4 Mapping Details/Browsers
Description: Predicted to have fibroblast growth factor receptor binding activity and growth factor activity. Involved in calcium ion homeostasis. Predicted to localize to the extracellular region. Human ortholog(s) of this gene implicated in autosomal dominant hypophosphatemic rickets. Is expressed in corpuscles of Stannius. Orthologous to human FGF23 (fibroblast growth factor 23).
Genome Resources: Alliance (1),  Gene:494456 (1),  Ensembl(GRCz11):ENSDARG00000045854 (1)
GENE EXPRESSION
All Expression Data: 12 figures from 7 publications
Wild-type Stages, Structures: Hatching:Long-pec (48.0h-60.0h) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa18050 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-fgf23 N/A 1
    MO2-fgf23 N/A 1
    PHENOTYPE
    Data: 2 figures from Lin et al., 2017
    Observed in:
    DISEASE ASSOCIATED WITH fgf23 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    autosomal dominant hypophosphatemic rickets Alliance Hypophosphatemic rickets, autosomal dominant 193100
    Osteomalacia, tumor-induced
    Tumoral calcinosis, hyperphosphatemic, familial, 2 617993
    DISEASE ASSOCIATED WITH fgf23 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process calcium ion homeostasis (more)
    Cellular Component extracellular region (more)
    Molecular Function fibroblast growth factor receptor binding (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR002209 (1)
  • InterPro:IPR008996 (1)
  • InterPro:IPR028304 (1)
  • Pfam:PF00167 (1)
  • TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA fgf23-201 (1)    Ensembl 919
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM fgf23 No data available
    MARKER RELATIONSHIPS
    fgf23 Contained in: [BAC] CH211-240J22 (1) (order this)
    fgf23 Encodes: [cDNA] MGC:194106 (1) (order this), MGC:194127 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001009564 (1) 806 bp
    Genomic GenBank:CR751235 (1) 104632 bp
    Select Tool
    Polypeptide UniProtKB:Q1L8M3 (1) 258 aa
    Sequence Clusters UniGene:92904 (1)
    Sequence Information (all 19)
    ORTHOLOGY for fgf23 ( Chr: 4 )
    CITATIONS (30)