Gene
pthlha
- ID
- ZDB-GENE-050119-9
- Name
- parathyroid hormone-like hormone a
- Symbol
- pthlha Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable hormone activity and peptide hormone receptor binding activity. Acts upstream of or within bone mineralization; dorsal aorta development; and embryonic cranial skeleton morphogenesis. Predicted to be located in extracellular region. Is expressed in several structures, including central nervous system; head; hypertrophic chondrocyte; perichondrium; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in brachydactyly type E2. Orthologous to human PTHLH (parathyroid hormone like hormone).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-pthlha | Hoyle et al., 2021 | |
| CRISPR2-pthlha | Hoyle et al., 2021 | |
| CRISPR3-pthlha | Hoyle et al., 2021 | |
| CRISPR4-pthlha | Hoyle et al., 2021 | |
| MO1-pthlha | N/A | Yan et al., 2012 |
| MO2-pthlha | N/A | Gray et al., 2013 |
1 - 6 of 6
Show
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| brachydactyly type E2 | Alliance | Brachydactyly, type E2 | 613382 |
1 - 1 of 1
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Parathyroid hormone/parathyroid hormone-related protein | Parathyroid hormone-related protein |
|---|---|---|---|---|
| UniProtKB:Q1L5E8 | InterPro | 198 |
1 - 1 of 1
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
pthlha-201
(1)
|
Ensembl | 1,242 nt | ||
| mRNA |
pthlha-202
(1)
|
Ensembl | 1,672 nt |
1 - 2 of 2
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-286M4 | ZFIN Curated Data | |
| Encodes | STS | zfish44907-3466f05.q1k | ||
| Encodes | cDNA | MGC:194291 | ZFIN Curated Data |
1 - 3 of 3
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | GenBank:GFIL01020067 (1) | 2042 nt | ||
| Genomic | GenBank:AL845512 | 192940 nt | ||
| Polypeptide | UniProtKB:Q1L5E8 (1) | 198 aa |
- Hoyle, D.J., Dranow, D.B., Schilling, T.F. (2021) Pthlha and mechanical force control early patterning of growth zones in the zebrafish craniofacial skeleton. Development (Cambridge, England). 149(2):
- Anneser, L., Alcantara, I.C., Gemmer, A., Mirkes, K., Ryu, S., Schuman, E.M. (2020) The neuropeptide Pth2 dynamically senses others via mechanosensation. Nature. 588(7839):653-657
- Chen, Z., Song, Z., Yang, J., Huang, J., Jiang, H. (2019) Sp7/osterix positively regulates dlx2b and bglap to affect tooth development and bone mineralization in zebrafish larvae. Journal of biosciences. 44(6):
- McMillan, S.C., Zhang, J., Phan, H.E., Jeradi, S., Probst, L., Hammerschmidt, M., Akimenko, M.A. (2018) A regulatory pathway involving retinoic acid and calcineurin demarcates and maintains joint cells and osteoblasts in the fin regenerate. Development (Cambridge, England). 145(11)
- Suarez-Bregua, P., Cal, L., Cañestro, C., Rotllant, J. (2017) PTH Reloaded: A New Evolutionary Perspective. Frontiers in Physiology. 8:776
- Suarez-Bregua, P., Torres-Nuñez, E., Saxena, A., Guerreiro, P., Braasch, I., Prober, D.A., Moran, P., Cerda-Reverter, J.M., Du, S.J., Adrio, F., Power, D.M., Canario, A.V., Postlethwait, J.H., Bronner, M.E., Cañestro, C., Rotllant, J. (2017) Pth4, an ancient parathyroid hormone lost in eutherian mammals, reveals a new brain-to-bone signaling pathway. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 31:569-583
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- On, J.S.W., Duan, C., Lee, L.T.O. (2015) Functional pairing of class B1 ligand-GPCR in cephalochordate provides evidence of the origin of PTH and PACAP/glucagonreceptor family. Molecular Biology and Evolution. 32(8):2048-59
- Gray, C., Bratt, D., Lees, J., Dacosta, M., Plant, K., Solaymani-Kohal, S., Tazzyman, S., Serbanovic-Canic, J., Crossman, D.C., Keavney, B.D., Haase, A., McMahon, K., Gering, M., Roehl, H., Evans, P.C., and Chico, T.J. (2013) Loss of Function of Parathyroid Hormone Receptor 1 Induces Notch-Dependent Aortic Defects During Zebrafish Vascular Development. Arterioscler. Thromb. Vasc. Biol.. 33(6):1257-63
- Mitchell, R.E., Huitema, L.F., Skinner, R.H., Brunt, L.H., Severn, C., Schulte-Merker, S., and Hammond, C.L. (2013) New tools for studying osteoarthritis genetics in zebrafish. Osteoarthritis and Cartilage. 21(2):269-278
1 - 10 of 17
Show