Gene
prkacaa
- ID
- ZDB-GENE-050114-6
- Name
- protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a
- Symbol
- prkacaa Nomenclature History
- Previous Names
-
- prkaca
- zgc:158799
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable cAMP-dependent protein kinase activity and protein kinase A regulatory subunit binding activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within protein phosphorylation. Predicted to be located in mitochondrion and plasma membrane. Predicted to be part of cAMP-dependent protein kinase complex. Predicted to be active in cytosol and nucleus. Is expressed in fin bud; hatching gland; nervous system; otic vesicle; and presumptive neural retina. Human ortholog(s) of this gene implicated in adrenal cortical adenoma; congestive heart failure; fibrolamellar carcinoma; platelet-type bleeding disorder 19; and primary pigmented nodular adrenocortical disease 4. Orthologous to several human genes including PRKACA (protein kinase cAMP-activated catalytic subunit alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Emerson et al., 2018
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| primary pigmented nodular adrenocortical disease 4 | Alliance | Cushing syndrome, ACTH-independent adrenal, somatic | 615830 |
| Cardioacrofacial dysplasia 1 | 619142 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR000961 | AGC-kinase, C-terminal |
| Family | IPR044109 | cAMP-dependent protein kinase catalytic subunit |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
Domain Details Per Protein
| Protein | Length | AGC-kinase, C-terminal | cAMP-dependent protein kinase catalytic subunit | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A3KMS9
|
352 | ||||||
|
UniProtKB:A0A8M9PZU3
|
389 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
prkacaa-201
(1)
|
Ensembl | 6,062 nt |
Interactions and Pathways
No data available
Plasmids
No data available