Gene

prkacaa

ID

ZDB-GENE-050114-6

Name

protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a

Symbol

prkacaa Nomenclature History

Previous Names

prkaca
zgc:158799

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Predicted to have protein kinase A regulatory subunit binding activity. Predicted to be involved in protein kinase A signaling. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in adrenal cortical adenoma; congestive heart failure; hypertrophic cardiomyopathy; and primary pigmented nodular adrenocortical disease. Orthologous to human PRKACA (protein kinase cAMP-activated catalytic subunit alpha).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Emerson et al., 2018

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With prkacaa Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
primary pigmented nodular adrenocortical disease 4	Alliance	Cushing syndrome, ACTH-independent adrenal, somatic	615830
		Cardioacrofacial dysplasia 1	619142

Associated With prkacaa Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000719	Protein kinase domain
Domain	IPR000961	AGC-kinase, C-terminal
Family	IPR044109	cAMP-dependent protein kinase catalytic subunit
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily