ZFIN ID: ZDB-GENE-050107-6
Gene Name: ectodysplasin A
Gene Symbol: eda    Nomenclature History

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Previous Names: nackt (1), nkt (1), si:ch73-223d24.5 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to have tumor necrosis factor receptor binding activity. Involved in bone development and odontogenesis. Predicted to localize to the membrane. Human ortholog(s) of this gene implicated in ectodermal dysplasia and tooth agenesis. Is expressed in dental mesenchyme; integument; pharyngeal arch; and pharynx. Orthologous to human EDA (ectodysplasin A).
Genome Resources: Alliance (1),  Gene:798740 (1),  Ensembl(GRCz11):ENSDARG00000074591 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
dt1261 Point Mutation Unknown Unknown ENU
la015662Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa31463 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa31464 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • DISEASE ASSOCIATED WITH eda HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    hypohidrotic ectodermal dysplasia Alliance Ectodermal dysplasia 1, hypohidrotic, X-linked 305100
    tooth agenesis Alliance Tooth agenesis, selective, X-linked 1 313500
    DISEASE ASSOCIATED WITH eda VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process bone development (more)
    Cellular Component membrane (more)
    Molecular Function tumor necrosis factor receptor binding (more)
    GO Terms (all 5)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR006052 Tumour necrosis factor domain
    Repeat IPR008160 Collagen triple helix repeat
    Homologous_superfamily IPR008983 Tumour necrosis factor-like domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA eda-201 (1)    Ensembl 1216
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM eda
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(Xla.Eef1a1:eda) eda Danio rerioXenopus laevis 1 3
    MARKER RELATIONSHIPS
    eda Contained in: [BAC] CH73-78E11 (1), CH73-223D24 (1), DKEY-48F17 (1) (order this)
    eda Contains: [STS] z35723-a1228g06.q1c (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001115065 (1) 1216 bp
    Genomic GenBank:AL954373 (1) 220092 bp Blast at MegaBLAST
    Polypeptide UniProtKB:B0YIF1 (1) 359 aa
    Sequence Information (all 18)
    ORTHOLOGY for eda ( Chr: 5 )
    CITATIONS (28)