Gene
sprn2
- ID
- ZDB-GENE-041221-1
- Name
- shadow of prion protein 2
- Symbol
- sprn2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to act upstream of or within protein homooligomerization. Located in cell surface. Is expressed in brain.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Strumbo et al., 2006
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa21716 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Homologous_superfamily | IPR036924 | Prion/Doppel beta-ribbon domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Prion/Doppel beta-ribbon domain superfamily |
|---|---|---|---|
| UniProtKB:Q65CB0 | InterPro | 135 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-81J8 | ZFIN Curated Data | |
| Encodes | EST | fj12d11 | ||
| Encodes | cDNA | MGC:123052 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:198278 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001007780 (1) | 1140 nt | ||
| Genomic | GenBank:BX640477 (1) | 258048 nt | ||
| Polypeptide | UniProtKB:Q65CB0 (1) | 135 aa |
No data available
- Lange, C., Rost, F., Machate, A., Reinhardt, S., Lesche, M., Weber, A., Kuscha, V., Dahl, A., Rulands, S., Brand, M. (2020) Single cell sequencing of radial glia progeny reveals diversity of newborn neurons in the adult zebrafish brain. Development (Cambridge, England). 147(1):
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Miesbauer, M., Bamme, T., Riemer, C., Oidtmann, B., Winklhofer, K.F., Baier, M., and Tatzelt, J. (2006) Prion protein-related proteins from zebrafish are complex glycosylated and contain a glycosylphosphatidylinositol anchor. Biochemical and Biophysical Research Communications. 341(1):218-224
- Rivera-Milla, E., Oidtmann, B., Panagiotidis, C.H., Baier, M., Sklaviadis, T., Hoffmann, R., Zhou, Y., Solis, G.P., Stuermer, C.A., and Malaga-Trillo, E. (2006) Disparate evolution of prion protein domains and the distinct origin of Doppel- and prion-related loci revealed by fish-to-mammal comparisons. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 20(2):317-319
- Strumbo, B., Sangiorgio, L., Ronchi, S., Gready, J.E., and Simonic, T. (2006) Cloning and analysis of transcripts and genes encoding fish-specific proteins related to PrP. Fish physiology and biochemistry. 32(4):339-353
- Premzl, M., Gready, J.E., Jermiin, L.S., Simonic, T., and0 Marshall Graves, J.A. (2004) Evolution of Vertebrate Genes Related to Prion and Shadoo Proteins—Clues from Comparative Genomic Analysis. Mol. Biol. Evol.. 21(12):2210-2231
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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