Gene
tfr1a
- ID
- ZDB-GENE-041220-1
- Name
- transferrin receptor 1a
- Symbol
- tfr1a Nomenclature History
- Previous Names
-
- chianti
- cia
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable transferrin receptor activity. Acts upstream of or within hemoglobin biosynthetic process; hemopoiesis; and intracellular iron ion homeostasis. Predicted to be located in melanosome and plasma membrane. Predicted to be active in external side of plasma membrane. Is expressed in hematopoietic system; kidney; presumptive blood; and ventral mesoderm. Human ortholog(s) of this gene implicated in breast carcinoma; immunodeficiency 46; multiple myeloma; and ovarian cancer. Orthologous to human TFRC (transferrin receptor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 10 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la028827Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa1799 | Allele with one point mutation | Unknown | Missense | ENU | |
| t20824 | Allele with one point mutation | Unknown | Missense | ENU | |
| t25302 | Allele with one point mutation | Unknown | Missense | ENU | |
| tp327 | Allele with one point mutation | Unknown | Missense | ENU | |
| tu25f | Allele with one point mutation | Donor Splice Site | Unknown | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-tfr1a | N/A | (2) |
| MO2-tfr1a | N/A | Wingert et al., 2004 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| immunodeficiency 46 | Alliance | Immunodeficiency 46 | 616740 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003137 | PA domain |
| Domain | IPR007365 | Transferrin receptor-like, dimerisation domain |
| Domain | IPR007484 | Peptidase M28 |
| Domain | IPR037324 | Transferrin receptor protein 1/2, PA domain |
| Family | IPR039373 | Transferrin receptor protein 1/Glutamate carboxypeptidase 2-like |
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Domain Details Per Protein
| Protein | Additional Resources | Length | PA domain | PA domain superfamily | Peptidase M28 | Transferrin receptor-like, dimerisation domain | Transferrin receptor-like, dimerisation domain superfamily | Transferrin receptor protein 1/2, PA domain | Transferrin receptor protein 1/Glutamate carboxypeptidase 2-like |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q5MPX4 | InterPro | 770 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-329G8 | ZFIN Curated Data | |
| Contained in | BAC | CH211-162E15 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194146 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001009917 (1) | 2313 nt | ||
| Genomic | GenBank:CU929154 (2) | 85598 nt | ||
| Polypeptide | UniProtKB:Q5MPX4 (1) | 770 aa |
- Guo, J., Zou, Z., Dou, X., Zhao, X., Wang, Y., Wei, L., Pi, Y., Wang, Y., He, C., Guo, S. (2024) Zebrafish Mbd5 binds to RNA m5C and regulates histone deubiquitylation and gene expression in development metabolism and behavior. Nucleic acids research. 52(8):4257-4275
- Lv, P., Liu, F. (2023) Heme-deficient primitive red blood cells induce HSPC ferroptosis by altering iron homeostasis during zebrafish embryogenesis. Development (Cambridge, England). 150(20):
- Wang, Y., Bo, J., Zhao, Z., Han, Y., Zhang, Q., Liu, L. (2023) Depletion of Igfbp7 alleviates zebrafish NAFLD progression through inhibiting hepatic ferroptosis. Life sciences. 332:122086
- Xie, L., Tao, Y., Shen, Z., Deng, H., Duan, X., Xue, Y., Chen, D., Li, Y. (2023) Congenital asplenia impairs heme-iron recycling during erythropoiesis in zebrafish. Developmental and comparative immunology. 151:105108
- Wu, M., Chen, Q., Li, J., Xu, Y., Lian, J., Liu, Y., Meng, P., Zhang, Y. (2022) Gfi1aa/Lsd1 Facilitates Hemangioblast Differentiation Into Primitive Erythrocytes by Targeting etv2 and sox7 in Zebrafish. Frontiers in cell and developmental biology. 9:786426
- Xi, J., Zhang, Z., Wang, Z., Wu, Q., He, Y., Xu, Y., Ding, Z., Zhao, H., Da, H., Zhang, F., Zhao, H., Fang, J. (2022) Hinokitiol functions as a ferroptosis inhibitor to confer neuroprotection. Free radical biology & medicine. 190:202-215
- Niksirat, H., Siino, V., Steinbach, C., Levander, F. (2021) High-Resolution Proteomic Profiling Shows Sexual Dimorphism in Zebrafish Heart-Associated Proteins. Journal of Proteome Research. 20(8):4075-4088
- Crispin, A., Guo, C., Chen, C., Campagna, D.R., Schmidt, P.J., Lichtenstein, D.A., Cao, C., Sendamarai, A.K., Hildick-Smith, G.J., Huston, N.C., Boudreaux, J., Bottomley, S.S., Heeney, M.M., Paw, B.H., Fleming, M.D., Ducamp, S. (2020) Mutations in the iron-sulfur cluster biogenesis protein HSCB cause congenital sideroblastic anemia. The Journal of Clinical Investigation. 130(10):5245-5256
- Lawson, N.D., Li, R., Shin, M., Grosse, A., Yukselen, O., Stone, O.A., Kucukural, A., Zhu, L. (2020) An improved zebrafish transcriptome annotation for sensitive and comprehensive detection of cell type-specific genes. eLIFE. 9:
- Wang, Y., Liu, X., Xie, B., Yuan, H., Zhang, Y., Zhu, J. (2019) The NOTCH1-dependent HIF1α/VGLL4/IRF2BP2 oxygen sensing pathway triggers erythropoiesis terminal differentiation. Redox Biology. 28:101313
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