Gene

tfr1a

ID

ZDB-GENE-041220-1

Name

transferrin receptor 1a

Symbol

tfr1a Nomenclature History

Previous Names

chianti
cia

Type

protein_coding_gene

Location

Chr: 2 Mapping Details/Browsers

Description

Predicted to have transferrin receptor activity. Involved in cellular iron ion homeostasis; hemoglobin biosynthetic process; and hemopoiesis. Predicted to localize to external side of plasma membrane. Human ortholog(s) of this gene implicated in breast carcinoma; multiple myeloma; ovarian cancer; and primary immunodeficiency disease. Is expressed in blood; blood island; intermediate cell mass of mesoderm; presumptive blood; and ventral mesoderm. Orthologous to human TFRC (transferrin receptor).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

9 figures from 7 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 10 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tfr1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
immunodeficiency 46	Alliance	Immunodeficiency 46	616740

Associated With tfr1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003137	PA domain
Domain	IPR007365	Transferrin receptor-like, dimerisation domain
Domain	IPR007484	Peptidase M28
Domain	IPR037324	Transferrin receptor protein 1/2, PA domain
Family	IPR039373	Transferrin receptor protein 1/Glutamate carboxypeptidase 2-like
Homologous_superfamily	IPR036757	Transferrin receptor-like, dimerisation domain superfamily
Homologous_superfamily	IPR046450	PA domain superfamily