Gene

prnpa

ID
ZDB-GENE-041217-6
Name
prion protein a
Symbol
prnpa Nomenclature History
Previous Names
  • prnp
  • PrP3 (1)
  • PrP-like (1)
  • PrP-rel-2 (1)
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Exhibits copper ion binding activity and superoxide dismutase activity. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in Creutzfeldt-Jakob disease; Gerstmann-Straussler-Scheinker syndrome; Huntington's disease-like 1; fatal familial insomnia; and kuru. Is expressed in heart; neuromast; pectoral fin; and pharyngeal arch 3-7 skeleton. Orthologous to human PRNP (prion protein).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Cotto et al., 2005
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With prnpa Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Creutzfeldt-Jakob disease Alliance Creutzfeldt-Jakob disease 123400
fatal familial insomnia Alliance Insomnia, fatal familial 600072
Gerstmann-Straussler-Scheinker syndrome Alliance Cerebral amyloid angiopathy, PRNP-related 137440
Gerstmann-Straussler-Scheinker syndrome Alliance Gerstmann-Straussler disease 137440
Huntington's disease-like 1 Alliance Huntington disease-like 1 603218
Spongiform encephalopathy with neuropsychiatric features 606688
{Kuru, susceptibility to} 245300
Associated With prnpa Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
No data available
Domain Details Per Protein
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations