ift27

ID

ZDB-GENE-041212-9

Name

intraflagellar transport 27 homolog (Chlamydomonas)

Symbol

ift27 Nomenclature History

Previous Names

rabl4
zgc:101893

Type

protein_coding_gene

Location

Ambiguous Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable GTP binding activity and GTPase activity. Acts upstream of or within cilium assembly; kidney development; and regulation of melanosome transport. Predicted to be part of intraciliary transport particle B. Predicted to be active in Golgi membrane and cilium. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome 19. Orthologous to human IFT27 (intraflagellar transport 27).

Genome Resources

Alliance (1)
Gene:494045 (1)

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

Alliance

High Throughput Data

Expression Atlas

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7148811 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 9 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ift27 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Bardet-Biedl syndrome 19	Alliance	Bardet-Biedl syndrome 19	615996

Associated With ift27 Via Experimental Models

Human Disease	Fish	Conditions	Citations
retinitis pigmentosa	ift27^{zf4178/zf4178} (AB)	standard conditions	Han et al., 2024

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR005225	Small GTP-binding domain
Family	IPR001806	Small GTPase
Family	IPR034112	Intraflagellar transport protein 27 homologue, eukaryotes
Family	IPR050227	Ras-related protein Rab
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase