Gene

mgme1

ID

ZDB-GENE-041212-68

Name

mitochondrial genome maintenance exonuclease 1

Symbol

mgme1 Nomenclature History

Previous Names

im:7154190
zgc:101650

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Description

Predicted to have single-stranded DNA exodeoxyribonuclease activity. Predicted to be involved in mitochondrial DNA replication. Predicted to localize to mitochondrion. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 11. Is expressed in several structures, including digestive system; lens; solid lens vesicle; vasculature; and ventral mesoderm. Orthologous to human MGME1 (mitochondrial genome maintenance exonuclease 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7154190 (8 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mgme1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
mitochondrial DNA depletion syndrome 11	Alliance	Mitochondrial DNA depletion syndrome 11	615084

Associated With mgme1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR038726	PD-(D/E)XK endonuclease-like domain, AddAB-type
Homologous_superfamily	IPR011335	Restriction endonuclease type II-like
Homologous_superfamily	IPR011604	PD-(D/E)XK endonuclease-like domain superfamily