Gene

iqcb1

ID

ZDB-GENE-041212-47

Name

IQ motif containing B1

Symbol

iqcb1 Nomenclature History

Previous Names

nphp5 (1)
zgc:101792

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Description

Predicted to have calmodulin binding activity. Involved in opsin transport and pronephros development. Human ortholog(s) of this gene implicated in Leber congenital amaurosis; Senior-Loken syndrome; nephronophthisis; and retinitis pigmentosa 3. Orthologous to human IQCB1 (IQ motif containing B1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

IMAGE:7146634 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With iqcb1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Senior-Loken syndrome	Alliance	Senior-Loken syndrome 5	609254

Associated With iqcb1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR000048	IQ motif, EF-hand binding site
Family	IPR028765	IQ calmodulin-binding motif-containing protein 1
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase

Domain Details Per Protein

Protein	Length	IQ calmodulin-binding motif-containing protein 1	IQ motif, EF-hand binding site	P-loop containing nucleoside triphosphate hydrolase
UniProtKB:A8KC58 InterPro	295
UniProtKB:Q5PRA5 InterPro	595
UniProtKB:A0A8M9QFC9 InterPro	470

Transcripts

Genome Browsers

UCSC

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	bx119909.1-201 (1) Ensembl	Havana	1264 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	iqcb1-201 (1) Ensembl	Havana	2581 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	iqcb1-202 (1) Ensembl	Havana	1633 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations