Gene
shank3b
- ID
- ZDB-GENE-041210-74
- Name
- SH3 and multiple ankyrin repeat domains 3b
- Symbol
- shank3b Nomenclature History
- Previous Names
-
- si:dkey-153k10.1
- zs3.1 (1)
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable ionotropic glutamate receptor binding activity and synaptic receptor adaptor activity. Acts upstream of or within intestinal motility. Predicted to be located in synapse. Predicted to be active in dendritic spine and postsynaptic density. Predicted to colocalize with postsynaptic membrane. Is expressed in brain; forebrain; and midbrain. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in Phelan-McDermid syndrome and schizophrenia 15. Orthologous to human SHANK3 (SH3 and multiple ankyrin repeat domains 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| fdu201 | Allele with one delins | Exon 2 | Frameshift, Premature Stop | CRISPR | |
| ihb687 | Allele with one deletion | Exon 12 | Unknown | CRISPR | |
| ihb688 | Allele with one deletion | Exon 12 | Unknown | CRISPR | |
| nv1061 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| nv1111 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| sa2155 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa33391 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa33392 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa45165 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| umi102 | Allele with one insertion | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-shank3b | (2) | |
| CRISPR2-shank3b | (4) | |
| CRISPR3-shank3b | Zebrafish Nomenclature Committee | |
| CRISPR4-shank3b | (2) | |
| MO1-shank3b | N/A | Ebarasi et al., 2009 |
| MO2-shank3b | N/A | Gauthier et al., 2010 |
| MO3-shank3b | N/A | Kozol et al., 2015 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Phelan-McDermid syndrome | Alliance | Phelan-McDermid syndrome | 606232 |
| schizophrenia 15 | Alliance | {Schizophrenia 15} | 613950 |
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| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| autism spectrum disorder | shank3bfdu201/fdu201 (TU) | standard conditions | Liu et al., 2018 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Ankyrin repeat | Ankyrin repeat-containing domain superfamily | PDZ domain | PDZ domain 6 | PDZ superfamily | SH3 and multiple ankyrin repeat domains protein | SH3 domain | SH3-like domain superfamily | Sterile alpha motif domain | Sterile alpha motif/pointed domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M6YZQ6
|
1605 | ||||||||||
|
UniProtKB:A0A8M6Z5I4
|
1636 | ||||||||||
|
UniProtKB:A0A8M6Z644
|
1551 | ||||||||||
|
UniProtKB:A0A8M9PQP9
|
1448 | ||||||||||
|
UniProtKB:A0A8M6YY75
|
1633 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
shank3b-201
(1)
|
Ensembl | 4,812 nt | ||
| mRNA |
shank3b-202
(1)
|
Ensembl | 5,490 nt | ||
| mRNA |
shank3b-203
(1)
|
Ensembl | 637 nt | ||
| mRNA |
shank3b-204
(1)
|
Ensembl | 4,617 nt | ||
| mRNA |
shank3b-205
(1)
|
Ensembl | 4,554 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-192L9 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-153K10 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_005164598 (1) | 7969 nt | ||
| Genomic | GenBank:BX901962 (1) | 182550 nt | ||
| Polypeptide | UniProtKB:A0A8M3ARK3 (1) | 1643 aa |
- Kozol, R.A., Dallman, J.E. (2023) Drugs prescribed for Phelan-McDermid syndrome differentially impact sensory behaviors in shank3 zebrafish models. F1000Research. 12:8484
- Rahmati-Holasoo, H., Salek Maghsoudi, A., Akbarzade, M., Gholami, M., Shadboorestan, A., Vakhshiteh, F., Armandeh, M., Hassani, S. (2023) Oxytocin protective effects on zebrafish larvae models of autism-like spectrum disorder. Iranian journal of basic medical sciences. 26:316325316-325
- Gabellini, C., Pucci, C., De Cesari, C., Martini, D., Di Lauro, C., Digregorio, M., Norton, W., Zippo, A., Sessa, A., Broccoli, V., Andreazzoli, M. (2022) CRISPR/Cas9-Induced Inactivation of the Autism-Risk Gene setd5 Leads to Social Impairments in Zebrafish. International Journal of Molecular Sciences. 24(1):
- Geng, Y., Zhang, T., Alonzo, I.G., Godar, S.C., Yates, C., Pluimer, B.R., Harrison, D.L., Nath, A.K., Yeh, J.J., Drummond, I.A., Bortolato, M., Peterson, R.T. (2022) Top2a promotes the development of social behavior via PRC2 and H3K27me3. Science advances. 8:eabm7069
- Baronio, D., Chen, Y.C., Panula, P. (2021) Abnormal brain development of monoamine oxidase mutant zebrafish and impaired social interaction of heterozygous fish. Disease models & mechanisms. 15(3):
- Kozol, R.A., James, D.M., Varela, I., Sumathipala, S.H., Züchner, S., Dallman, J.E. (2021) Restoring Shank3 in the rostral brainstem of shank3ab-/- zebrafish autism models rescues sensory deficits. Communications biology. 4:1411
- Liu, C., Wang, Y., Deng, J., Lin, J., Hu, C., Li, Q., Xu, X. (2021) Social Deficits and Repetitive Behaviors Are Improved by Early Postnatal Low-Dose VPA Intervention in a Novel shank3-Deficient Zebrafish Model. Frontiers in neuroscience. 15:682054
- Tang, W., Davidson, J.D., Zhang, G., Conen, K.E., Fang, J., Serluca, F., Li, J., Xiong, X., Coble, M., Tsai, T., Molind, G., Fawcett, C.H., Sanchez, E., Zhu, P., Couzin, I.D., Fishman, M.C. (2020) Genetic Control of Collective Behavior in Zebrafish. iScience. 23:100942
- Chestnut, B., Sumanas, S. (2019) Zebrafish etv2 knock-in line labels vascular endothelial and blood progenitor cells. Developmental Dynamics : an official publication of the American Association of Anatomists. 249(2):245-261
- James, D.M., Kozol, R.A., Kajiwara, Y., Wahl, A.L., Storrs, E.C., Buxbaum, J.D., Klein, M., Moshiree, B., Dallman, J.E. (2019) Intestinal dysmotility in a zebrafish (Danio rerio) shank3a;shank3b mutant model of autism. Molecular autism. 10:3
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