Gene
itih5
- ID
- ZDB-GENE-041210-193
- Name
- inter-alpha-trypsin inhibitor heavy chain 5
- Symbol
- itih5 Nomenclature History
- Previous Names
-
- si:dkey-235i4.2
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to act upstream of or within hyaluronan metabolic process and negative regulation of peptidase activity. Predicted to be located in extracellular region. Orthologous to human ITIH5 (inter-alpha-trypsin inhibitor heavy chain 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la024525Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la024526Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa8448 | Allele with one point mutation | Unknown | Unknown | ENU | |
| sa8581 | Allele with one point mutation | Unknown | Unknown | ENU | |
| sa20287 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR002035 | von Willebrand factor, type A |
| Domain | IPR010600 | Inter-alpha-trypsin inhibitor heavy chain, C-terminal |
| Domain | IPR013694 | VIT domain |
| Family | IPR050934 | Inter-alpha-trypsin inhibitor heavy chain |
| Homologous_superfamily | IPR036465 | von Willebrand factor A-like domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Inter-alpha-trypsin inhibitor heavy chain | Inter-alpha-trypsin inhibitor heavy chain, C-terminal | VIT domain | von Willebrand factor A-like domain superfamily | von Willebrand factor, type A |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M1PU27 | InterPro | 981 | |||||
| UniProtKB:A0A8M3ARJ3 | InterPro | 751 | |||||
| UniProtKB:A0AB32TN95 | InterPro | 980 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-235I4 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001030088 (1) | |||
| Genomic | GenBank:BX537116 (1) | 117841 nt | ||
| Polypeptide | UniProtKB:A0A8M1PU27 (1) | 981 aa |
- Mehjabin, R., Chen, L., Huang, R., Zhu, D., Yang, C., Li, Y., Liao, L., He, L., Zhu, Z., Wang, Y. (2019) Expression and localization of grass carp pkc-θ (protein kinase C theta) gene after its activation. Fish & shellfish immunology. 87:788-795
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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