ZFIN ID: ZDB-GENE-041210-173
Gene Name: synthesis of cytochrome C oxidase 2
Gene Symbol: sco2    Nomenclature History

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Previous Name: si:dkey-202b22.3

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 4 Mapping Details/Browsers
Description: Predicted to have protein disulfide oxidoreductase activity. Predicted to be involved in eye development and mitochondrial respiratory chain complex IV assembly. Predicted to localize to the integral component of mitochondrial inner membrane. Human ortholog(s) of this gene implicated in cytochrome-c oxidase deficiency disease; fatal infantile cardioencephalomyopathy due to cytochrome c oxidase deficiency 1; hypertrophic cardiomyopathy; and myopia. Orthologous to human SCO2 (synthesis of cytochrome C oxidase 2).
Genome Resources: Alliance (1),  Gene:606683 (1),  Ensembl(GRCz11):ENSDARG00000045555 (2)
GENE EXPRESSION No data available
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa40273 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH sco2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    fatal infantile cardioencephalomyopathy due to cytochrome c oxidase deficiency 1 Alliance Cardioencephalomyopathy, fatal infantile, due to cytochrome c oxidase deficiency 1 604377
    myopia Alliance Myopia 6 608908
    DISEASE ASSOCIATED WITH sco2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process eye development (more)
    Cellular Component integral component of mitochondrial inner membrane (more)
    Molecular Function protein disulfide oxidoreductase activity (more)
    GO Terms (all 13)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Family IPR003782 Copper chaperone SCO1/SenC
    Family IPR017276 Synthesis of cytochrome c oxidase, Sco1/Sco2
    Homologous_superfamily IPR036249 Thioredoxin-like superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA sco2-201 (1)    Ensembl 985
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM sco2 No data available
    MARKER RELATIONSHIPS
    sco2 Contained in: [BAC] DKEY-202B22 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001045232 (1) 843 bp
    Genomic GenBank:BX649398 (1) 166156 bp
    Select Tool
    Polypeptide UniProtKB:Q5RH02 (1) 279 aa
    Sequence Information (all 9)
    ORTHOLOGY for sco2 ( Chr: 4 )
    CITATIONS (21)