Gene

ncf4

ID

ZDB-GENE-041124-1

Name

neutrophil cytosolic factor 4

Symbol

ncf4 Nomenclature History

Previous Names

p40phox (1)

Type

protein_coding_gene

Location

Chr: 22 Mapping Details/Browsers

Description

Predicted to have phosphatidylinositol binding activity and superoxide-generating NADPH oxidase activator activity. Predicted to be involved in superoxide metabolic process. Predicted to localize to NADPH oxidase complex. Human ortholog(s) of this gene implicated in autosomal recessive chronic granulomatous disease cytochrome b-positive type III. Orthologous to human NCF4 (neutrophil cytosolic factor 4).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2005

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu789 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ncf4 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal recessive chronic granulomatous disease 3	Alliance	Chronic granulomatous disease 3, autosomal recessive	613960

Associated With ncf4 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000270	PB1 domain
Domain	IPR001452	SH3 domain
Domain	IPR001683	Phox homology
Domain	IPR034853	Neutrophil cytosol factor P40, PB1 domain
Domain	IPR034912	Neutrophil cytosol factor 4, PX domain
Domain	IPR035541	Neutrophil cytosol factor P40, SH3 domain
Domain	IPR053793	PB1-like domain
Family	IPR000919	Neutrophil cytosol factor P40
Family	IPR051228	NADPH Oxidase and PX Domain-Containing
Homologous_superfamily	IPR036028	SH3-like domain superfamily
Homologous_superfamily	IPR036871	PX domain superfamily