Gene
haao
- ID
- ZDB-GENE-041114-89
- Name
- 3-hydroxyanthranilate 3,4-dioxygenase
- Symbol
- haao Nomenclature History
- Previous Names
-
- zgc:103585
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable 3-hydroxyanthranilate 3,4-dioxygenase activity and ferrous iron binding activity. Predicted to be involved in 'de novo' NAD biosynthetic process from L-tryptophan and quinolinate biosynthetic process. Predicted to act upstream of or within pyridine nucleotide biosynthetic process. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in intestinal bulb and liver. Orthologous to human HAAO (3-hydroxyanthranilate 3,4-dioxygenase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:103585 (5 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| vcc13 | Allele with one deletion | Exon 13 | Unknown | TALEN |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| TALEN1-haao | Zebrafish Nomenclature Committee |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Vertebral, cardiac, renal, and limb defects syndrome 1 | 617660 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | 3-hydroxyanthranilate 3, 4-dioxygenase, metazoan | 3-hydroxyanthranilic acid dioxygenase | RmlC-like cupin domain superfamily | RmlC-like jelly roll fold |
|---|---|---|---|---|---|---|
| UniProtKB:B2GQ93 | InterPro | 287 | ||||
| UniProtKB:F1QYC7 | InterPro | 287 | ||||
| UniProtKB:Q5U3F8 | InterPro | 287 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-33C4 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:103585 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191824 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001007390 (1) | 1076 nt | ||
| Genomic | GenBank:CU570986 (2) | 74996 nt | ||
| Polypeptide | UniProtKB:B2GQ93 (1) | 287 aa |
- Wu, T.S., Lin, Y.T., Huang, Y.T., Yu, F.Y., Liu, B.H. (2019) Ochratoxin A triggered intracerebral hemorrhage in embryonic zebrafish: Involvement of microRNA-731 and prolactin receptor. Chemosphere. 242:125143
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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