Gene
tnni2a.1
- ID
- ZDB-GENE-041114-60
- Name
- troponin I type 2a (skeletal, fast), tandem duplicate 1
- Symbol
- tnni2a.1 Nomenclature History
- Previous Names
-
- tropI-1a (1)
- zgc:103650
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable actin binding activity. Predicted to be involved in cardiac muscle contraction and skeletal muscle contraction. Predicted to be part of troponin complex. Is expressed in myotome. Human ortholog(s) of this gene implicated in arthrogryposis multiplex congenita; distal arthrogryposis type 2B1; and intrinsic cardiomyopathy (multiple). Orthologous to several human genes including TNNI2 (troponin I2, fast skeletal type).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:103650 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| distal arthrogryposis type 2B1 | Alliance | Arthrogryposis, distal, type 2B1 | 601680 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Troponin | Troponin domain superfamily | Troponin I |
|---|---|---|---|---|
|
UniProtKB:Q5U3E9
|
178 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
tnni2a.1-201
(1)
|
Ensembl | 780 nt | ||
| mRNA |
tnni2a.1-202
(1)
|
Ensembl | 826 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-9F16 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:103650 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192049 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001007365 (1) | 847 nt | ||
| Genomic | GenBank:CU302206 (1) | 53614 nt | ||
| Polypeptide | UniProtKB:Q5U3E9 (1) | 178 aa |
- Comparative Orthology
- Alliance
- Gene Tree
- Ensembl
- Note
- tnni2a.1, tnni2a.2, tnni2a.3, and tnni2a.4 form a cluster on chromosome 25 and are likely the result of tandem duplications. The location of the cluster in zebrafish as well as the amino acid identity of all genes in the cluster support orthology to human TNNI2 and mouse Tnni2.
- Takashima, S., Takemoto, S., Toyoshi, K., Ohba, A., Shimozawa, N. (2021) Zebrafish model of human Zellweger syndrome reveals organ-specific accumulation of distinct fatty acid species and widespread gene expression changes. Molecular genetics and metabolism. 133(3):307-323
- Demin, K.A., Lakstygal, A.M., Krotova, N.A., Masharsky, A., Tagawa, N., Chernysh, M.V., Ilyin, N.P., Taranov, A.S., Galstyan, D.S., Derzhavina, K.A., Levchenko, N.A., Kolesnikova, T.O., Mor, M.S., Vasyutina, M.L., Efimova, E.V., Katolikova, N., Prjibelski, A.D., Gainetdinov, R.R., de Abreu, M.S., Amstislavskaya, T.G., Strekalova, T., Kalueff, A.V. (2020) Understanding complex dynamics of behavioral, neurochemical and transcriptomic changes induced by prolonged chronic unpredictable stress in zebrafish. Scientific Reports. 10:19981
- Zhang, X., Zhou, Q., Li, X., Zou, W., Hu, X. (2020) Integrating omics and traditional analyses to profile the synergistic toxicity of graphene oxide and triphenyl phosphate. Environmental pollution (Barking, Essex : 1987). 263:114473
- Genge, C.E., Stevens, C.M., Davidson, W.S., Singh, G., Tieleman, D.P., Tibbits, G.F. (2016) Functional divergence in teleost cardiac troponin paralogs guides variation in the interaction of TnI switch region with TnC. Genome biology and evolution. 8(4):994-1011
- Gomes, R.S., Skroblin, P., Munster, A.B., Tomlins, H., Langley, S.R., Zampetaki, A., Yin, X., Wardle, F., Mayr, M. (2016) "Young at heart": Regenerative potential linked to immature cardiac phenotypes. Journal of Molecular and Cellular Cardiology. 92:105-8
- Shih, Y.H., Zhang, Y., Ding, Y., Ross, C.A., Li, H., Olson, T.M., Xu, X. (2015) Cardiac Transcriptome and Dilated Cardiomyopathy Genes in Zebrafish. Circulation. Cardiovascular genetics. 8(2):261-9
- Day, K.R., and Jagadeeswaran, P. (2009) Microarray analysis of prothrombin knockdown in zebrafish. Blood cells, molecules & diseases. 43(2):202-210
- Macqueen, D.J., and Johnston, I.A. (2008) An Update on MyoD Evolution in Teleosts and a Proposed Consensus Nomenclature to Accommodate the Tetraploidization of Different Vertebrate Genomes. PLoS One. 3(2):e1567
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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