Gene

gnb4b

ID

ZDB-GENE-041114-167

Name

guanine nucleotide binding protein (G protein), beta polypeptide 4b

Symbol

gnb4b Nomenclature History

Previous Names

zgc:101614

Type

protein_coding_gene

Location

Chr: 11 Mapping Details/Browsers

Description

Predicted to be involved in signal transduction. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease dominant intermediate F. Is expressed in head; neuromast; and posterior lateral line primordium. Orthologous to human GNB4 (G protein subunit beta 4).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With gnb4b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Charcot-Marie-Tooth disease dominant intermediate F	Alliance	Charcot-Marie-Tooth disease, dominant intermediate F	615185

Associated With gnb4b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR019775	WD40 repeat, conserved site
Domain	IPR001632	G-protein, beta subunit
Family	IPR016346	Guanine nucleotide-binding protein, beta subunit
Homologous_superfamily	IPR015943	WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily	IPR036322	WD40-repeat-containing domain superfamily
Repeat	IPR001680	WD40 repeat
Repeat	IPR020472	G-protein beta WD-40 repeat

Domain Details Per Protein

Protein	Length	G-protein, beta subunit	G-protein beta WD-40 repeat	Guanine nucleotide-binding protein, beta subunit	WD40 repeat	WD40 repeat, conserved site	WD40-repeat-containing domain superfamily	WD40/YVTN repeat-like-containing domain superfamily
UniProtKB:Q5U3U8 InterPro	279
UniProtKB:A0A2R8RKX9 InterPro	340

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	gnb4b-201 (1) Ensembl	Ensembl		4,276 nt	Select Tool ZFIN BLAST
mRNA	gnb4b-202 (1) Ensembl	Ensembl		872 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations